8-硝基-6-喹啉羧酸 | 157915-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 8-硝基-6-喹啉羧酸
• 英文名称: 8-nitroquinoline-6-carboxylic acid
• 英文别名: 8-nitro-quinoline-6-carboxylic acid；8-Nitro-chinolin-6-carbonsaeure；6-carboxy-8-nitroquinoline
• CAS: 157915-07-6
• 化学式: C₁₀H₆N₂O₄
• mdl: MFCD07440068
• 分子量: 218.169
• InChiKey: IFLJJCFENDRBKS-UHFFFAOYSA-N

物化性质

• 沸点：
  414.8±40.0 °C(Predicted)
• 密度：
  1.545±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  8-硝基-6-喹啉羧酸 在 palladium 10% on activated carbon 、 甲酸铵 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以99%的产率得到8-amino-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
  参考文献：
  名称：

  [EN] HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS
  [FR] DÉRIVÉS AROMATIQUES HÉTÉROCYCLIQUES POUR LE TRAITEMENT DE TROUBLES LIÉS À LA FERROPTOSE

  摘要：

  本申请公开了异双环和非异双环芳香衍生物化合物和组合物，以及利用本文所披露的化合物和组合物治疗患者的铁死亡相关疾病和疾病的方法。

  公开号：

  WO2019106434A1
• 作为产物：
  描述：

  甘油 、 4-氨基-3-硝基苯甲酸 在 硫酸 、 硝基苯 作用下， 生成 8-硝基-6-喹啉羧酸
  参考文献：
  名称：

  DE533691

  摘要：

  公开号：

文献信息

• Monoacylglycerol Lipase Modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US20200102311A1

  公开（公告）日：2020-04-02

  Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R 2 , R 3 R 4 , R 5 and R 6 are defined herein.

  桥接化合物，其结构式为(I)和(II)，包含它们的药物组合物，制造它们的方法，以及使用它们的方法，包括用于治疗与MGL调节相关的疾病状态、障碍和状况的方法，如与疼痛、精神障碍、神经障碍（包括但不限于重性抑郁障碍、难治性抑郁、焦虑性抑郁、双相情感障碍）、癌症和眼科疾病相关的方法。 其中R2、R3、R4、R5和R6的定义如下。
• Carbapenem antibiotic compounds
  申请人：Zeneca Limited

  公开号：US05441949A1

  公开（公告）日：1995-08-15

  The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; P.sup.1 is of the formula: ##STR2## and one or two of A,B,C,D,E,F,G and H, are nitrogen and the remainder are CH; and P is bonded to the nitrogen of the linking carbamoyl group by a carbon atom, in either ring, is substituted by the carboxy group on a carbon atom, in either ring, and is optionally further substituted, by up to three substitutents, on a carbon atom, in either ring; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them are also described.

  本发明涉及碳青霉烯类药物，并提供了一种具有化学式（I）的化合物 其中：R.sup.1为1-羟乙基，1-氟乙基或羟甲基；R.sup.2为氢或C.sub.1-4烷基；R.sup.3为氢或C.sub.1-4烷基；P.sup.1为以下式的一部分：并且A、B、C、D、E、F、G和H中的一个或两个为氮，其余为CH；P通过碳原子与连接的羰基基团的氮键合，在环的任一环上，均被羧基取代，或在环的任一环上，可进一步被最多三个取代基取代；或其药学上可接受的盐或体内水解酯。还描述了其制备过程，制备中间体，作为治疗剂的用途以及含有它们的药物组合物。
• Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f[quinoline complexes of cobalt and chromium
  申请人：——

  公开号：US20040138195A1

  公开（公告）日：2004-07-15

  This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

  本发明涉及一类杂环及其金属配合物，特别关注这些化合物在制备前药或作为前药的使用，这些前药可以在缺氧条件下通过酶或治疗性电离辐射被激活，用于治疗癌症。本发明还涉及这些杂环及其相应的金属配合物在制备药物中的使用，以及包括这些杂环或其金属配合物的组合物和制备这些化合物的方法。
• Anti-cancer 2,3-dihydro-1H-pyrrole[3,2-f] quinoline compolexes of cobalt and chromium
  申请人：Denny Alexander William

  公开号：US20050038249A1

  公开（公告）日：2005-02-17

  This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

  本发明涉及一类杂环及其金属络合物，特别关注这些化合物在制备前药或作为前药的使用，这些前药可以在缺氧条件下通过酶或治疗性电离辐射激活，用于治疗癌症。该发明还涉及这些杂环和相应的金属络合物在制备药物中的应用，以及包括这些杂环或其金属络合物的组合物和制备这些化合物的方法。
• Anti-cancer 2,3-dihydro-1H-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium
  申请人：Auckland Uniservices Limited

  公开号：US07064117B2

  公开（公告）日：2006-06-20

  This invention relates to a class of heterocycles and their metal complexes, and is particularly concerned with the use of these compounds in the preparation of prodrugs or as prodrugs that may be activated under hypoxic conditions by enzymes or by therapeutic ionising radiation, in the treatment of cancer. The invention also relates to the use of these heterocycles and the corresponding metal complexes in the preparation of medicaments and to compositions including the heterocycles or their metal complexes and to methods for preparing these compounds.

  本发明涉及一类杂环及其金属配合物，特别涉及这些化合物在制备前药或作为前药的使用，可在缺氧条件下通过酶或治疗性电离辐射激活，用于癌症治疗。本发明还涉及使用这些杂环和相应的金属配合物制备药物，以及包括这些杂环或其金属配合物的组合物和制备这些化合物的方法。