4-t-Butyl-cycloheptanol | 5932-63-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-t-Butyl-cycloheptanol
• 英文别名: 4-Tert-butylcycloheptan-1-ol
• CAS: 5932-63-8
• 化学式: C₁₁H₂₂O
• 分子量: 170.295
• InChiKey: YPWOCRYXPMKZAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯酐 、 4-t-Butyl-cycloheptanol 在 吡啶 作用下， 生成 4-t-Butyl-cycloheptyl saures Phthalat
  参考文献：
  名称：

  Cycloheptanol. Steric Influence of the 4-t-Butyl Group

  摘要：

  DOI：

  10.1021/jo01023a541
• 作为产物：
  描述：

  4-tert-Butyl-cycloheptanon 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 4-t-Butyl-cycloheptanol
  参考文献：
  名称：

  Peters,J.A.; van Bekkum,H., Recueil des Travaux Chimiques des Pays-Bas, 1971, vol. 90, p. 65 - 80

  摘要：

  DOI：

文献信息

• HEPATITIS B ANTIVIRAL AGENTS
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20170253609A1

  公开（公告）日：2017-09-07

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R  (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了以下式(I)的化合物，或其药学上可接受的盐、酯或前药： X-A-Y-L-R  (I) 这些化合物抑制由乙型肝炎病毒（HBV）编码的蛋白质或干扰HBV生命周期的功能，并且还可用作抗病毒剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HBV感染的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。
• Production Of Polyketides And Other Natural Products
  申请人：Gregory Matthew Alan

  公开号：US20090253732A1

  公开（公告）日：2009-10-08

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及聚酮类化合物和其他天然产物的生产，以及化合物库和独特新化合物的制备。因此，本发明提供了17-去甲基拉帕霉素及其类似物，包括重组菌株的制备方法，以及本发明化合物的分离和用途。此外，本发明还提供了将17-去甲基拉帕霉素及其类似物用于诱导或维持免疫抑制、促进神经再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥、移植物抗宿主病、自身免疫性疾病、炎症性血管疾病和纤维化疾病的调节。
• 17-Desmethylrapamycin and analogues thereof, methods for their production and their use as immunosupressants, anticancer agents, antifungal agents etc.
  申请人：Biotica Technology Limited

  公开号：EP2471797A2

  公开（公告）日：2012-07-04

  The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in one aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.

  本发明涉及多酮类化合物和其他天然产物的生产，以及化合物库和单个新型化合物。因此，在一个方面，本发明提供了 17-去甲基拉帕霉素及其类似物、其生产方法（包括重组菌株）以及本发明化合物的分离和用途。在另一个方面，本发明提供了17-去甲基拉帕霉素及其类似物在诱导或维持免疫抑制、刺激神经元再生或治疗癌症、B细胞恶性肿瘤、真菌感染、移植排斥反应、移植物对宿主疾病、自身免疫性疾病、炎症性血管疾病和纤维化疾病以及调节伤口愈合中的用途。
• PROCESS FOR PRODUCING ALDEHYDE COMPOUND OR KETONE COMPOUND WITH USE OF MICROREACTOR
  申请人：Ube Industries, Ltd.

  公开号：EP1710223B1

  公开（公告）日：2012-10-31
• Method for producing aldehyde compound or ketone compound by using microreactor
  申请人：Ataka Kikuo

  公开号：US20070149823A1

  公开（公告）日：2007-06-28

  The method for producing an aldehyde or ketone compound from a corresponding primary or secondary alcohol at relatively high temperature within a short time with a high yield including a step (1) of reacting a sulfoxide compound with an activating agent to produce an activation reaction product; a step (2) of reacting the activation reaction product with a primary or secondary alcohol to produce an alkoxysulfonium salt; and a step (3) of reacting the reaction product with a base to produce an aldehyde or ketone; wherein at least one of the steps, preferably the step (1) and step (2), are carried out by using a microreactor.