3-methyl-1,2-dithiolane | 55487-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: 3-methyl-1,2-dithiolane
• 英文别名: 3-methyldithiolane
• CAS: 55487-20-2
• 化学式: C₄H₈S₂
• 分子量: 120.24
• InChiKey: YGRXDUYBUNBNHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3-二溴丁烷 在 piperidinium thiotungstate 作用下， 反应 4.0h， 以61%的产率得到3-methyl-1,2-dithiolane
  参考文献：
  名称：

  Novel alkylation with tetrathiotungstates and tetrathiomolybdates: facile synthesis of disulfides from alkyl halides

  摘要：

  DOI：

  10.1021/jo00274a002

文献信息

• Piperidinium tetrathiotungstate as sulfur transfer reagent: synthesis of cyclic disulfides
  作者：Preeti Dhar、Nallaperumal Chidambaram、Srinivasan Chandrasekaran

  DOI：10.1021/jo00032a019

  日期：1992.3

  Piperidinium tetrathiotungstate has been found to react with a number of 1,n-dihalo compounds to afford the corresponding cyclic disulfides in good yields, under mild reaction conditions. This new methodology has been used as a key step in the synthesis of (+/-)-lipoic acid (35) and asparagusic acid (37).
• Novel alkylation with tetrathiotungstates and tetrathiomolybdates: facile synthesis of disulfides from alkyl halides
  作者：Preeti Dhar、Srinivasan Chandrasekaran

  DOI：10.1021/jo00274a002

  日期：1989.6
• Synthesis of cyclic disulfides using didecyldimethylammonium bromide as phase transfer catalyst
  作者：Sachin U. Sonavane、Mandan Chidambaram、Sanaa Khalil、Joseph Almog、Yoel Sasson

  DOI：10.1016/j.tetlet.2007.11.075

  日期：2008.1

  A convenient, practical and general method for the synthesis of symmetrical and unsymmetrical cyclic disulfides based on the reaction of sulfur with sodium sulfide in the presence of didecyldimethylammonium bromide (DDAB) as a phase transfer catalyst is described. (C) 2007 Published by Elsevier Ltd.