2,6-cyclo-norbornane-3,5-diol | 6975-11-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,6-cyclo-norbornane-3,5-diol
• 英文别名: 2,6-Cyclo-norbornan-3,5-diol；Tricyclo[2.2.1.02,6]heptane-3,5-diol
• CAS: 6975-11-7；17290-02-7
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: QQLNWTFCRIBMEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,5-diacetoxy-2,6-cyclo-norbornane 在 sodium hydroxide 作用下， 生成 2,6-cyclo-norbornane-3,5-diol
  参考文献：
  名称：

  Energy Intake, Body Mass Index, Physical Activity, and the Colorectal Adenoma-Carcinoma Sequence

  摘要：

  Little is known about the precise relationship between energy intake, overweight, sedentary lifestyle, and steps in the colorectal adenoma-carcinoma pathway. We studied these parameters within a case-control study. Patients with adenomas < 10 mm (n = 154) or > 10 min (n = 208) were compared with polyp-free controls (n = 426) for determining factors associated with adenoma formation, i.e., observed for small and large adenomas, or with adenoma growth only. Colorectal cancer cases (n = 171) were compared with population controls (n = 309) to determine factors specific to the final stage, cancer. Exercise reduced the risk of cancer [odds ratio (OR) = 0.3, 95% confidence interval (CI) = 0.2-0.5 for high vs. low physical activity] but had little influence on adenomas. High energy intake increased the risk of cancer [OR for 5th vs. 1st quintile (OR5) = 1.6, 95% CI = 0.9-2.9, p = 0.02], but not of adenomas. High body mass index (BMI) significantly increased the risk of large adenomas (OR, = 2.1, 95% CI = 1.2-3.5, p = 0. 02 and OR5 = 1.7, 95% CI = 1.0-3.1, p = 0.25) for large and small adenomas vs. polyp-free controls. Neither height nor weight nor BMI influenced the risk of cancer. Results were unmodified when controlling for dietary risk factors and family history. Energy intake, a sedentary lifestyle, and high BMI were independently associated with a high risk of cancer use for large adenomas, which indicates an effect on promotion of colorectal tumors. These findings suggest that preventive advice regarding these factors should be provided, even late in life, to decrease the risk of colorectal cancer.

  DOI：

  10.1207/s15327914nc391_7

文献信息

• Some Chlorine Derivatives of Norbornane (Bicyclo[2.2.1]heptane)
  作者：John D. Roberts、Frederick O. Johnson、Rudolph A. Carboni

  DOI：10.1021/ja01651a027

  日期：1954.11

  The endo-cis and trans-5,6-dichloronorbornenes were prepared by the respective additions of cis- and trans-dichlorocthylene to cyclopentadiene. The sterochemical assigments were confirmed by dipole moment studies. The cis-dichloride was inert to hydrolysis while the trans isomer was hydrolyzed to 3,5-dihydroxynortricyclene. Hydrogenation of the dichloride isomers gave the endo-cis- and trans-2,3-dichloronorbornanes

  内顺式和反式 5,6-二氯降冰片烯是通过将顺式和反式二氯乙烯分别加入环戊二烯来制备的。通过偶极矩研究证实了立体化学分配。顺式二氯化物对水解呈惰性，而反式异构体水解为 3,5-二羟基降三环烯。二氯化物异构体的氢化得到内-顺-和反-2,3-二氯降冰片烷。与基于卤化氢优先反式消除的预期相反，饱和的顺式二氯化物似乎比反式异构体更不容易脱卤化氢，尽管在两种情况下反应都很慢。两种异构体产生相同的脱卤化氢产物，2-氯降冰片烯，其结构通过氧化为顺式-环戊烷-1,3-二羧酸和水解为降樟脑而得到证实。降冰片烯在 - 75o 下氯化得到降三环基氯和 syn-7-exo-2-dichloronorbornane。由于化合物对脱卤化氢试剂的相对惰性，后者的结构被指定（优先于外-顺-2,3-二氯降冰片烷）。内-顺-2,3-二氯降冰片烷不容易水解，但反式-2,3-二氯降冰片烷和syn-7-exo-2-二氯降冰片烷分别水
• Studies in the Bicyclo[2.2.1]heptane Series. V. Reactions of Bicyclo[2.2.1]heptadiene¹
  作者：GEORGE T. YOUNGBLOOD、C. D. TRIVETTE、PELHAM WILDER

  DOI：10.1021/jo01099a011

  日期：1958.5
• US2730548
  申请人：——

  公开号：——

  公开（公告）日：——
• DE1001259
  申请人：——

  公开号：——

  公开（公告）日：——
• HAIR RELAXING AND STRAIGHTENING COMPOSITIONS
  申请人：International Flora Technologies, Ltd.

  公开号：EP2648675A1

  公开（公告）日：2013-10-16