9-乙基双环[3.3.1]壬烷-9-醇 | 21915-33-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 9-乙基双环[3.3.1]壬烷-9-醇
• 中文别名: 9-乙基双环[3.3.1]壬-9-醇
• 英文名称: 9-ethyl[3.3.1]bicyclononan-9-ol
• 英文别名: 9-ethylbicyclo(3.3.1)nonan-9-ol；9-ethylbicyclo[3.3.1]nona-9-ol；9-ethylbicyclo[3.3.1]nonan-9-ol
• CAS: 21915-33-3
• 化学式: C₁₁H₂₀O
• 分子量: 168.279
• InChiKey: COQRKPRIDRDOOG-UHFFFAOYSA-N

物化性质

• 沸点：
  80-85 °C(Press: 0.01 Torr)
• 密度：
  0.968±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906199090

反应信息

• 作为反应物：
  描述：

  9-乙基双环[3.3.1]壬烷-9-醇 、 苯甲酰氯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 2.0h， 以74%的产率得到9-ethyl[3.3.1]bicyclononan-9-ol benzoate
  参考文献：
  名称：

  N-Benzoyl-4-(dimethylamino)pyridinium Chloride: Isolation and Use for the Direct Benzoylation of Alcohols

  摘要：

  A simple method for the formation and isolation of N-benzoyl-4-(dimethylamino) pyridinium chloride is described. This reagent can be employed directly for the benzoylation of secondary and tertiary alcohols.

  DOI：

  10.1080/00397919708005004
• 作为产物：
  描述：

  1,5-cis,cis-cyclooctadiene 、 乙烯 、 一氧化碳 生成 9-乙基双环[3.3.1]壬烷-9-醇
  参考文献：
  名称：

  The reaction of carbon monoxide with B-alkyl-9-borabicyclo[3.3.1]nonanes. A remarkably simple synthesis of 9-alkylbicyclo[3.3.1.]nonan-9-ols

  摘要：

  DOI：

  10.1021/ja01021a048

文献信息

• Bioactive peptides
  申请人：ALPHARMA AS

  公开号：US20030022821A1

  公开（公告）日：2003-01-30

  The present invention provides a modified lactoferrin peptide which is cytotoxic, 7 to 25 amino acids in length, with three or more cationic residues and which has one or more extra bulky and lipophilic amino acids as compared to the native lactoferrin sequence, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing such peptides, pharmaceutical compositions containing such peptides and use of the peptides as medicaments, particularly as antibacterials or anti-tumoural agents.

  本发明提供一种改性乳铁蛋白肽，其具有细胞毒性，长度为7至25个氨基酸，含有三个或更多阳离子残基，并且与天然乳铁蛋白序列相比，具有一个或多个额外的笨重和亲脂氨基酸，以及其酯、酰胺、盐和环状衍生物，以及制备这些肽的方法、含有这些肽的药物组合物和将这些肽用作药物的用途，特别是作为抗菌或抗肿瘤剂。
• [EN] COMPOUNDS CONTAINING SIX-MEMBERED RINGS, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS<br/>[FR] COMPOSES CONTENANT DES CHAINES FERMEES A SIX ELEMENTS, PROCEDES DE PREPARATION DE CES COMPOSES, ET LEUR UTILISATION COMME MEDICAMENTS
  申请人：GILEAD SCIENCES, INC.

  公开号：WO1999014185A1

  公开（公告）日：1999-03-25

  (EN) Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.(FR) L'invention concerne de nouveaux composés qui, en général, comprennent un groupe acide, un groupe basique, un amino ou N-acyl à substitution et un groupe comportant une fraction alcane facultativement hydroxylée. L'invention concerne également des compositions pharmaceutiques renfermant les inhibiteurs décrits. L'invention concerne en outre des procédés qui permettent d'inhiber la neuraminidase dans des échantillons dont on suspecte qu'ils contiennent ladite neuraminidase. L'invention concerne enfin des matériaux antigéniques, des polymères, des anticorps, des conjugués des composés considérés munis de marqueurs, et des procédés de dosage qui permettent de déceler l'activité de la neuraminidase.

  （中文）描述了一些新化合物。这些化合物通常包括一个酸性基团、一个碱性基团、一个取代的氨基或N-酰基和一个具有可选的羟基化烷基部分的基团。还描述了包含该发明的抑制剂的制药组合物。还描述了在怀疑含有神经氨酸酶的样品中抑制神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、带有标记的该发明化合物的结合物以及用于检测神经氨酸酶活性的测定方法。
• Antimicrobial compounds and formulations
  申请人：——

  公开号：US20030195144A1

  公开（公告）日：2003-10-16

  The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipoophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilising microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

  本发明涉及使用分子制造药物，该分子包括长度为2至35个非氢原子的骨架，至少连接有两个笨重和亲脂性基团，并且具有至少一个阳离子多于阴离子的基团，用作破坏微生物细胞膜的药物，并且涉及使用包括长度为2至35个非氢原子的骨架的分子，该分子共价连接有一个超级笨重和亲脂性基团，包括至少9个非氢原子，并且具有至少两个阳离子多于阴离子的基团，作为膜作用抗微生物药物的用途，以及涉及此类分子的治疗方法，特别是包括肽衍生物和肽类似物的肽。
• NOVEL COMPOUNDS AND METHODS FOR SYNTHESIS AND THERAPY
  申请人：BISCHOFBERGER NORBERT W.

  公开号：US20050176758A1

  公开（公告）日：2005-08-11

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  本发明涉及新型化合物。该化合物通常包含一个酸性基团、一个碱性基团、一个取代的氨基或N-酰基和一个具有可选羟基化的烷基部分。本发明还涉及包含所述抑制剂的制药组合物。还描述了用于抑制怀疑含有神经氨酸酶的样品中神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、标记化合物的结合物以及用于检测神经氨酸酶活性的测定方法。
• Inhibition of tumour growth
  申请人：Eliassen Tone Liv

  公开号：US20080019993A1

  公开（公告）日：2008-01-24

  The present invention provides a cytotoxic 7 to 25 mer peptide with three or more cationic residues which has one or more non-genetic bulky and lipophilic amino acids, as well as esters, amides, salts and cyclic derivatives thereof as well as methods of preparing the peptides, pharmaceutical compositions containing them and their use as medicaments, particularly as antibacterions or antitumoural agents. In a preferred aspect, the invention provides the use of said peptides in a method of inducing adaptive immunity against tumour growth or establishment in a subject, as well as the use of other lytic agents in a method of inducing adaptive immunity in a subject.

  本发明提供了一种细胞毒性的7至25个氨基酸残基的肽，其中含有三个或更多阳离子残基，其中含有一个或多个非遗传性的臃肿和亲脂性氨基酸，以及它们的酯类、酰胺、盐和环状衍生物，以及制备这些肽的方法、含有它们的药物组合物以及它们作为药物的用途，特别是作为抗菌或抗肿瘤剂。在一个优选方面，本发明提供了利用所述肽在主体中诱导适应性免疫反应以抑制肿瘤生长或建立的方法，以及利用其他溶解剂在主体中诱导适应性免疫反应的方法。

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