9-氨基-1-甲基-吖啶 | 23045-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 9-氨基-1-甲基-吖啶
• 英文名称: 5-Amino-4-methylacridin
• 英文别名: 1-methyl-acridin-9-ylamine；Acridine, 9-amino-1-methyl-；1-methylacridin-9-amine
• CAS: 23045-11-6
• 化学式: C₁₄H₁₂N₂
• 分子量: 208.263
• InChiKey: QDFZZUZHYOGLPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  9-氨基-1-甲基-吖啶 、 乙酸酐 生成 N-(1-methyl-acridin-9-yl)-diacetamide
  参考文献：
  名称：

  32.一些5-氨基ac啶的乙酰化

  摘要：

  DOI：

  10.1039/jr9460000115
• 作为产物：
  描述：

  1-methylacridin-9(10H)-one 生成 9-氨基-1-甲基-吖啶
  参考文献：
  名称：

  32.一些5-氨基ac啶的乙酰化

  摘要：

  DOI：

  10.1039/jr9460000115

文献信息

• Albert; Gledhill, Journal of the Society of Chemical Industry, 1945, vol. 64, p. 169,170
  作者：Albert、Gledhill

  DOI：——

  日期：——
• Pd-catalyzed one-pot approach for installation of 9-aminoacridines via Buchwald-Hartwig amination and cycloaromatization
  作者：Kovuru Gopalaiah、Renu Choudhary、K. R. S. Sambasiva Rao

  DOI：10.24820/ark.5550190.p011.823

  日期：——
• METHODS AND COMPOSITION FOR DETERMINING PH
  申请人：The University of Chicago

  公开号：EP3298151A1

  公开（公告）日：2018-03-28
• US4462993A
  申请人：——

  公开号：US4462993A

  公开（公告）日：1984-07-31
• [EN] METHODS AND COMPOSITION FOR DETERMINING PH<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR DÉTERMINER LE PH
  申请人：UNIV CHICAGO

  公开号：WO2016187284A1

  公开（公告）日：2016-11-24

  Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.