9-氨基-10-甲基吖啶 | 951-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 9-氨基-10-甲基吖啶
• 英文名称: 9-Amino-10-methylacridinium
• 英文别名: 10-methylacridin-10-ium-9-amine
• CAS: 951-01-9
• 化学式: C14H13N2+
• 分子量: 209.27
• InChiKey: SQFZLHHJWJODCA-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.9
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

文献信息

• FLUORESCENT DYES BASED ON ACRIDINE AND ACRIDINIUM DERIVATIVES
  申请人：Almac Sciences (Scotland) Limited

  公开号：US20140349297A1

  公开（公告）日：2014-11-27

  The present invention relates to fluorescent dyes based on acridine and acridinium derivatives and use of such dyes in for example, biochemical and/or cell-based assays.

  本发明涉及基于吖啶和吖啶盐衍生物的荧光染料及其在生物化学和/或基于细胞的分析中的应用。
• DEVICE FOR DETECTION OF HALOGENATED HYDROCARBONS
  申请人：Masarykova univerzita

  公开号：EP3173487A1

  公开（公告）日：2017-05-31

  The present invention provides a device for detection of halogenated aliphatic hydrocarbons which contains a carrier with at least one indicator of presence of halogenated aliphatic hydrocarbons, and at least one haloalkane dehalogenase (EC 3.8.1.5) immobilized on the surface of said carrier. Further provided is a method of detecting at least one halogenated aliphatic hydrocarbon in a sample or environment, wherein the sample or environment is contacted with said device which is pre-treated by hydration, and the chemical change of the indicator of presence of halogenated aliphatic hydrocarbons is evaluated.

  本发明提供了一种检测卤代脂族烃的装置，该装置包含一个载体，载体上至少有一个卤代脂族烃存在的指示剂，以及固定在所述载体表面的至少一个卤代烃脱卤酶（EC 3.8.1.5）。 进一步提供了一种检测样品或环境中至少一种卤代脂族烃的方法，其中样品或环境与经过水合预处理的所述装置接触，并评估卤代脂族烃指示剂的化学变化。
• Methods and compositions for determining pH
  申请人：The University of Chicago

  公开号：US11136618B2

  公开（公告）日：2021-10-05

  Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO. 6) wherein C is cytosine; X, Y and Z are each one or more of adenine, thymine, guanine, or combinations thereof; and n is greater than or equal to 2; and wherein at least 2 cytosine residues of the first single-stranded nucleic acid molecule are modified; and a second single-stranded nucleic acid molecule that is partially or fully complementary to the first single-stranded molecule, wherein a first label is conjugated to the first single-stranded nucleic acid molecule or the second single-stranded nucleic acid molecule; and wherein the first label is capable of producing a signal, wherein the intensity of the signal varies as a function of the conformation of the nucleic acid complex; and measuring the intensity of the signal and determining the pH from the measured signal.

  本文描述了可用作 i 开关 pH 报告器的核酸分子和复合物，它们作为 pH 报告器具有更高的灵敏度，并具有替代的 pH 报告能力范围。本公开的各个方面涉及一种测定 pH 值的方法，该方法包括提供一种核酸复合物，该核酸复合物包含：第一单链核酸分子，该核酸分子包含序列 CnXCnYCnZCn（SEQ ID NO.6)，其中 C 是胞嘧啶；X、Y 和 Z 分别是腺嘌呤、胸腺嘧啶、鸟嘌呤或其组合中的一种或多种；以及 n 大于或等于 2；并且其中第一单链核酸分子的至少 2 个胞嘧啶残基被修饰；和与第一单链分子部分或完全互补的第二单链核酸分子，其中第一标签与第一单链核酸分子或第二单链核酸分子共轭；其中第一标签能够产生信号，信号强度随核酸复合物构象的变化而变化；以及测量信号强度并根据测量的信号确定 pH 值。
• METHODS AND COMPOSITION FOR DETERMINING PH
  申请人：The University of Chicago

  公开号：EP3298151A1

  公开（公告）日：2018-03-28
• OLIGONUCLEOTIDES COMPRISING SIGNALLING PAIRS AND HYDROPHOBIC NUCLEOTIDES, STEMLESS BEACONS, FOR DETECTION OF NUCLEIC ACIDS, METHYLATION STATUS AND MUTANTS OF NUCLEIC ACIDS
  申请人：Christensen Ulf Bech

  公开号：US20100068704A1

  公开（公告）日：2010-03-18

  The invention relates to novel oligonucleotides comprising a signalling pair and at least hydrophobic nucleotide. The oligonucleotide analogues are useful for detecting the status of nucleic acid sequences, such as presence, expression, methylation and/or mutation, in particular single point mutations and other sequences where the variation between the correct target and other targets may vary in as little as one nucleotide. The invention also relates to new ways of detecting sequence differences and optimizing conditions by using oligonucleotide analogues and readily available instruments. In particular the invention relates to specifically detecting quantity of a target nucleic acids or detecting one sequence over others that may vary in as little as one nucleotide using oligonucleotides or oligonucleotide analogues comprising a signalling pair and at least one hydrophobic nucleotide, such as a nucleotide analogue comprising an intercalator.