2'-Hydroxy-3'-jod-4-methoxy-chalkon | 1226-07-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2'-Hydroxy-3'-jod-4-methoxy-chalkon
• 英文别名: 3'-Iod-2'-hydroxy-4-methoxy-chalkon；2'-hydroxy-3'-iodo-4-methoxychalcone；1-(2-hydroxy-3-iodophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
• CAS: 1226-07-9
• 化学式: C₁₆H₁₃IO₃
• 分子量: 380.182
• InChiKey: XWMBPGGEAIEUIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2'-羟基苯乙酮 在 碘 、 碘酸 、 sodium hydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 、 水 、 mineral oil 为溶剂， 反应 17.25h， 生成 3'-iodo-4'-methoxyflavanone 、 2'-Hydroxy-3'-jod-4-methoxy-chalkon 、 2'-hydroxy-α,β-diiodo-4-methoxydihydrochalcone 、 2'-hydroxy-3,3',5'-triiodo-4-methoxychalcone
  参考文献：
  名称：

  Synthesis and antifungal activities of natural and synthetic biflavonoids

  摘要：

  The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.04.010

文献信息

• Synthesis and antifungal activities of natural and synthetic biflavonoids
  作者：Gabriel Sagrera、Ana Bertucci、Alvaro Vazquez、Gustavo Seoane

  DOI：10.1016/j.bmc.2011.04.010

  日期：2011.5

  The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.