9-羟基-5,8a-二甲基-1-亚甲基-3a,4,5,5a,6,7,9,9a-八氢薁并[7,6-d]呋喃-2,8-二酮 | 63568-73-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 9-羟基-5,8a-二甲基-1-亚甲基-3a,4,5,5a,6,7,9,9a-八氢薁并[7,6-d]呋喃-2,8-二酮
• 英文名称: Sesquiterpene lactone TS-6
• 英文别名: 9-hydroxy-5,8a-dimethyl-1-methylidene-3a,4,5,5a,6,7,9,9a-octahydroazuleno[6,7-b]furan-2,8-dione
• CAS: 63568-73-0
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.32
• InChiKey: IOUNDPHKKPZPKB-UHFFFAOYSA-N

物化性质

• 沸点：
  460.1±45.0 °C(Predicted)
• 密度：
  1.22±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Personal care article and method for inhibiting attachment of yeast to skin
  申请人：——

  公开号：US20030224034A1

  公开（公告）日：2003-12-04

  A personal care article including an isoprenoid compound, and a method of inhibiting attachment of pathogenic fungi to skin using an isoprenoid compound in combination with a personal care article. The isopreniod compound may be farnesol, which is particularly effective against the pathogenic yeast Candida albicans.

  一种包括异戊二烯化合物的个人护理用品，以及一种使用异戊二烯化合物与个人护理用品相结合抑制致病真菌附着皮肤的方法。异戊二烯化合物可以是法尼醇，它对致病性酵母菌 白色念珠菌。
• PERSONAL CARE ARTICLE AND METHOD FOR INHIBITING ATTACHMENT OF YEAST TO SKIN
  申请人：KIMBERLY-CLARK WORLDWIDE, INC.

  公开号：EP1509181A1

  公开（公告）日：2005-03-02
• [EN] PERSONAL CARE ARTICLE AND METHOD FOR INHIBITING ATTACHMENT OF YEAST TO SKIN<br/>[FR] ARTICLE DE SOIN PERSONNEL ET PROCEDE EMPECHANT L'ADHERENCE DES CHAMPIGNONS A LA PEAU
  申请人：KIMBERLY CLARK CO

  公开号：WO2003101356A1

  公开（公告）日：2003-12-11

  A personal care article including an isoprenoid compound, and a method of inhibiting attachment of pathogenic fungi to skin using an isoprenoid compound in combination with a personal care article. The isopreniod compound may be farnesol, which is particularly effective against the pathogenic yeast Candida albicans.
• [EN] COMPOSITIONS AND METHODS OF TREATMENT COMPRISING PLANT EXTRACTS<br/>[FR] COMPOSITIONS ET METHODES DE TRAITEMENT AU MOYEN D'EXTRAITS DE PLANTES
  申请人：GELSTAT CORP

  公开号：WO2004112819A1

  公开（公告）日：2004-12-29

  Methods of treating a disease associated with prolonged or excessive activation of NF-kB are provided, comprising administering a composition comprising at least one plant extract from a plant that is a source of sesquiterpene lactone, or a composition comprising a sesquiterpene lactone in an effective amount to a patient in need thereof. In a preferred embodiment, the plant extract is extracted from feverfew, and the sesquiterpene lactone is parthenolide. In a preferred embodiment of the invention, the composition is administered via a route that bypasses the GI tract. In another preferred embodiment of the invention, the composition is administered in an amount of active ingredient that is surprisingly low.