3-(1-(cyclohex-1-en-1-yl)ethyl)quinoline | 1386394-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(1-(cyclohex-1-en-1-yl)ethyl)quinoline
• 英文别名: 3-[1-(Cyclohexen-1-yl)ethyl]quinoline；3-[1-(cyclohexen-1-yl)ethyl]quinoline
• CAS: 1386394-19-9
• 化学式: C₁₇H₁₉N
• 分子量: 237.345
• InChiKey: KQNAAFUYZRUDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烯 、 1,1,2,2,3,3,4,4,4-九氟丁烷-1-磺酸环己-1-烯基酯 、 3-喹啉硼酸频哪醇酯 在 tris-(dibenzylideneacetone)dipalladium(0) 、 碳酸氢钠 、 二苄叉丙酮 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 55.0 ℃ 、103.42 kPa 条件下， 反应 36.0h， 以89%的产率得到3-(1-(cyclohex-1-en-1-yl)ethyl)quinoline
  参考文献：
  名称：

  Palladium-Catalyzed 1,1-Difunctionalization of Ethylene

  摘要：

  The 1,1-difunctionalization of ethylene, with aryl/vinyl/heteroaryl transmetalating agents and vinyl electrophiles, is reported. The reaction is high-yielding under a low pressure of ethylene, and regioselectivity is generally high for the 1,1-disubstituted product. The process is highlighted by the use of heteroaromatic cross-coupling reagents, which have not been competent reaction partners in previously reported efforts.

  DOI：

  10.1021/ja304344h

文献信息

• Palladium-Catalyzed 1,1-Difunctionalization of Ethylene
  作者：Vaneet Saini、Matthew S. Sigman

  DOI：10.1021/ja304344h

  日期：2012.7.18

  The 1,1-difunctionalization of ethylene, with aryl/vinyl/heteroaryl transmetalating agents and vinyl electrophiles, is reported. The reaction is high-yielding under a low pressure of ethylene, and regioselectivity is generally high for the 1,1-disubstituted product. The process is highlighted by the use of heteroaromatic cross-coupling reagents, which have not been competent reaction partners in previously reported efforts.