6-[(7-Chloroquinolin-1-ium-4-yl)amino]hexanoate | 1019368-66-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[(7-Chloroquinolin-1-ium-4-yl)amino]hexanoate
• CAS: 1019368-66-1
• 化学式: C₁₅H₁₇ClN₂O₂
• 分子量: 292.765
• InChiKey: CSKBIMWNXMTFPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 6-[(7-Chloroquinolin-1-ium-4-yl)amino]hexanoate 在 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  4-Aminoquinoline-β-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

  摘要：

  A library of quinoline‐β‐lactam‐based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N‐1 substituent of the β‐lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.

  DOI：

  10.1111/cbdd.12225
• 作为产物：
  描述：

  4,7-二氯喹啉 、 6-氨基己酸 以 苯酚 为溶剂， 反应 18.0h， 生成 6-[(7-Chloroquinolin-1-ium-4-yl)amino]hexanoate
  参考文献：
  名称：

  4-Aminoquinoline-β-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation

  摘要：

  A library of quinoline‐β‐lactam‐based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N‐1 substituent of the β‐lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.

  DOI：

  10.1111/cbdd.12225

文献信息

• 4-Aminoquinoline-<i>β</i>-Lactam Conjugates: Synthesis, Antimalarial, and Antitubercular Evaluation
  作者：Raghu Raj、Christophe Biot、Séverine Carrère-Kremer、Laurent Kremer、Yann Guérardel、Jiri Gut、Philip J. Rosenthal、Vipan Kumar

  DOI：10.1111/cbdd.12225

  日期：2014.2

  A library of quinoline‐β‐lactam‐based hybrids was synthesized and tested for their antimalarial and antitubercular activities. The present antimalarial data showed the dependence of activity on the nature of linker, N‐1 substituent of the β‐lactam ring as well as the length of alkyl chain. Most of the compounds are not as efficient as chloroquine in inhibiting the culture growth of Plasmodium falciparum W2 strain. Nevertheless, the synthesized hybrids showed better antitubercular activities (up to five times) compared with cephalexin (up to three times) and ethionamide.