9-N-[8-[(2-aminoacridin-9-yl)amino]octyl]acridine-2,9-diamine | 67003-28-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-N-[8-[(2-aminoacridin-9-yl)amino]octyl]acridine-2,9-diamine
• CAS: 67003-28-5
• 化学式: C₃₄H₃₆N₆
• 分子量: 528.7
• InChiKey: CYZZEAILYKQOFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  9-N-[8-[(2-aminoacridin-9-yl)amino]octyl]acridine-2,9-diamine 、 1,8-二辛酰氯 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 70.0h， 以31%的产率得到2,11,19,24,33,38-hexazaheptacyclo[32.10.2.220,23.012,21.013,18.037,45.039,44]octatetraconta-1(45),12(21),13,15,17,19,22,34(46),35,37,39,41,43,47-tetradecaene-25,32-dione
  参考文献：
  名称：

  New α,ω-diamido and α,ω-diamino mono-and bi-bridged acridine dimers

  摘要：

  A novel set of dimers derived from 9-amino acridine was prepared and characterized by H-1 and C-13 NMR. These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of alpha,omega-diamido or alpha,omega-diamino side-chains. Additionally the preparation of some bi-bridged compounds was achieved.

  DOI：

  10.1007/bf00808507
• 作为产物：
  描述：

  1,8-辛二胺 在 氢溴酸 作用下， 以 戊醇 为溶剂， 反应 26.0h， 生成 9-N-[8-[(2-aminoacridin-9-yl)amino]octyl]acridine-2,9-diamine
  参考文献：
  名称：

  New α,ω-diamido and α,ω-diamino mono-and bi-bridged acridine dimers

  摘要：

  A novel set of dimers derived from 9-amino acridine was prepared and characterized by H-1 and C-13 NMR. These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of alpha,omega-diamido or alpha,omega-diamino side-chains. Additionally the preparation of some bi-bridged compounds was achieved.

  DOI：

  10.1007/bf00808507

文献信息

• New α,ω-diamido and α,ω-diamino mono-and bi-bridged acridine dimers
  作者：Martine Moisan、Jean-Pierre Galy、Anne-Marie Galy、Jacques Barbe

  DOI：10.1007/bf00808507

  日期：1993.1

  A novel set of dimers derived from 9-amino acridine was prepared and characterized by H-1 and C-13 NMR. These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of alpha,omega-diamido or alpha,omega-diamino side-chains. Additionally the preparation of some bi-bridged compounds was achieved.