D-脯氨酰胺盐酸盐 | 50894-62-7

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 天然氨基酸及其衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: D-脯氨酰胺盐酸盐
• 英文名称: (R)-prolinamide hydrochloride
• 英文别名: D-Pro-NH2*HCl；H-Pro-NH2 hydrochloride；prolinamide hydrochloride；(R)-Pyrrolidine-2-carboxamide hydrochloride；(2R)-pyrrolidine-2-carboxamide;hydrochloride
• CAS: 50894-62-7
• 化学式: C₅H₁₀N₂O*ClH
• 分子量: 150.608
• InChiKey: CSKSDAVTCKIENY-PGMHMLKASA-N

物化性质

• 熔点：
  170-182°C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.35
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.1
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 储存条件：
  -15°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: H-D-Pro-NH2 HCl
Synonyms: D-Prolinamide HCl

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: H-D-Pro-NH2 HCl
CAS number: 50894-62-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C5H10N2O.ClH
Molecular weight: 150.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  三苯基氯甲烷 、 D-脯氨酰胺盐酸盐 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以93%的产率得到(R)-(+)-N-tritylprolinamine
  参考文献：
  名称：

  PYRIDINOPYRIDINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

  摘要：

  本发明涉及公式（I）的吡啶吡啶酮衍生物，其中变量如本文所定义，涉及其制备以及作为PDGF（血小板源性生长因子）配体受体激酶活性抑制剂以及可能的FLT3（类似Fms酪氨酸激酶受体）配体受体的治疗用途。

  公开号：

  US20110124643A1

文献信息

• Rapid, one-pot synthesis of urethane-protected tripeptides
  作者：Yun-Fei Zhu、William D. Fuller

  DOI：10.1016/0040-4039(94)02391-n

  日期：1995.2

  Urethane-protected tripeptides are synthesized in solution, without isolation or purification of intermediates, using urethane-protected N-carboxyanhydrides as coupling reagents and hydrogenation for removal of N-protection.

  氨基甲酸酯保护的三肽是在溶液中合成的，无需分离或纯化中间体，使用氨基甲酸酯保护的N-羧基酸酐作为偶联剂并进行氢化以去除N-保护。
• [EN] 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES<br/>[FR] DÉRIVÉS D'ACIDE 3,5-DIAMINO-6-CHLOROPYRAZINE-2-CARBOXYLIQUE ET LEUR UTILISATION COMME BLOQUEUR DU CANAL SODIQUE ÉPITHÉLIAL POUR LE TRAITEMENT DE MALADIES DES VOIES AÉRIENNES
  申请人：NOVARTIS AG

  公开号：WO2009138378A1

  公开（公告）日：2009-11-19

  A compound of Formula (I) in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

  公式（I）的化合物以自由或盐或溶剂形式存在，其中R1、R2、R3、R4、R5、R6、R7、R8和R9的含义如规范中所示，对于治疗对上皮钠通道阻滞有响应的疾病是有用的。还描述了含有这些化合物的药物组合物以及制备这些化合物的方法。
• Hoegberg, Thomas; Raemsby, Sten; Stroem, Peter, Acta Chemica Scandinavica, 1989, vol. 43, # 7, p. 660 - 664
  作者：Hoegberg, Thomas、Raemsby, Sten、Stroem, Peter

  DOI：——

  日期：——
• Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2
  作者：Cesare Giordano、Anna Sansone、Annalisa Masi、Gino Lucente、Pasqualina Punzi、Adriano Mollica、Francesco Pinnen、Federica Feliciani、Ivana Cacciatore、Peg Davis

  DOI：10.1016/j.ejmech.2010.07.022

  日期：2010.10

  The opioid agonists endomorphins (Tyr-Pro-Trp-Phe-NH(2); EM1 and Tyr-Pro-Phe-Phe-NH(2); EM2) and morphiceptin (Tyr-Pro-Phe-Pro-NH(2)) exhibit an extremely high selectivity for mu-opioid receptor. Here a series of novel EM2 and morphiceptin analogues containing in place of the proline at position 2 the S and R residues of beta-homologues of proline (HPro), of 2-pyrrolidinemethanesulphonic acid (HPrs) and of 3-pyrrolidinesulphonic acid (beta Prs) have been synthesized and their binding affinity and functional activity have been investigated. The highest p-receptor affinity is shown by [(S)beta Prs(2)]EM2 analogue (6e) which represents the first example of a beta-sulphonamido analogue in the field of mold peptides. (C) 2010 Elsevier Masson SAS. All rights reserved.
• 3,5-DIAMINO-6-CHLORO-PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS EPITHELIAL SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ARWAY DISEASES
  申请人：Novartis AG

  公开号：EP2285785B1

  公开（公告）日：2012-09-05