D-苯丙氨酰胺 | 5241-59-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: D-苯丙氨酰胺
• 英文名称: D-Phenylalaninamide
• 英文别名: D-phenylalanine amide；(R)-2-amino-3-phenylpropanamide；H-D-Phe-NH2；(2R)-2-amino-3-phenylpropanamide
• CAS: 5241-59-8
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: OBSIQMZKFXFYLV-MRVPVSSYSA-N

物化性质

• 熔点：
  234-237 °C (decomp)
• 沸点：
  356.9±35.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于氯仿（轻微，加热），甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  应存放在室温、避光且充满惰性气体的环境中。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: H-D-Phe-NH2
Synonyms: D-Phenylalaninamide

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: H-D-Phe-NH2
CAS number: 5241-59-8

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H12N2O
Molecular weight: 164.2

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  D-苯丙氨酰胺 在 伯吉斯试剂 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (+/-)-3-phenyl-2-(1-piperidinyl)propanenitrile
  参考文献：
  名称：

  非外消旋单立体中心α-氨基腈的制备及其在Bruylants反应中的去向研究

  摘要：

  研究了许多手性羧酰胺脱水方法，以制备仅具有一个立体生成中心的四个代表性的对映异构体富集的α-氨基腈。使用Burgess盐（产率高达87％，er高达92/8）或三氟乙酸酐-三乙胺组合（产率高达98％，er高达86/14）观察到最佳结果。将如此获得的两个氨基腈与甲基格氏试剂进行Bruylants反应，得到相应的叔胺；这些产物以及任何未反应的起始原料基本上以外消旋形式获得。根据该反应的公认机理，镁元素与亚胺的形成有关，亚胺是化学转化和外消旋过程的常用中间体。

  DOI：

  10.1016/j.tet.2006.09.087
• 作为产物：
  描述：

  D-苯丙氨酸 在 氯化亚砜 、 氨 作用下， 以 甲醇 为溶剂， 反应 111.0h， 生成 D-苯丙氨酰胺
  参考文献：
  名称：

  Brunner; Kroiss; Schmidt, European Journal of Medicinal Chemistry, 1986, vol. 21, # 4, p. 333 - 338

  摘要：

  DOI：
• 作为试剂：
  描述：

  1-苯基-3,4-二氢异喹啉 在 C₄₂H₆₄Cl₄Ir₂N₆O₄S₂ 、 D-苯丙氨酰胺 作用下， 以 二甲基亚砜 为溶剂， 反应 18.25h， 以16%的产率得到
  参考文献：
  名称：

  基于生物素-链霉亲和素技术扩大人工亚胺还原酶的化学多样性

  摘要：

  我们报告了基于生物素-链霉亲和素技术的人工亚胺还原酶的优化。为了快速产生化学多样性，公开了用于形成和评估生物素化复合物的新策略。将生物素锚链束缚到Cp *部分上，可在ad 6金属上留下三个自由配位位点，用于通过各种配体的配位引入化学多样性。为了验证这一概念，筛选了34个双齿配体，并在存在21个链霉亲和素（Sav）同工型的情况下测试了6种最佳配体的选择，以制得由此产生的三支腿式钢琴凳配合物，从而实现不对称亚胺还原。对映纯α-氨基酰胺被鉴定为有前途的双齿配体：ee高达63％以[IrCp *生物素（L- ThrNH 2）Cl]⊂SavWT为催化剂，在形成1-苯基-1,2,3,4-四氢异喹啉中获得了190次转换。

  DOI：

  10.1002/cctc.201300825

文献信息

• Activation of carboxylic acids by pyrocarbonates. Application of di-tert-butyl pyrocarbonate as condensing reagent in the synthesis of amides of protected amino acids and peptides
  作者：Vladimir F. Pozdnev

  DOI：10.1016/0040-4039(95)01412-b

  日期：1995.9

  Amides formation from protected amino acids and peptides was achieved in an easy and convenient one-pot procedure using di-tert-butyl pyrocarbonate as activating agent in the presence of pyridine and ammonium hydrogencarbonate. The method gave good yields and did not induce racemization during the amidation of urethane protected amino acids.

  在吡啶和碳酸氢铵存在下，使用焦碳酸二叔丁酯作为活化剂，通过一种简便的一锅法，可以从受保护的氨基酸和肽形成酰胺。该方法在氨基甲酸酯保护的氨基酸的酰胺化过程中获得了良好的收率并且没有引起外消旋作用。
• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20060223855A1

  公开（公告）日：2006-10-05

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  描述了用于治疗或预防与淀粉样蛋白相关疾病的方法、化合物、药物组合物和试剂盒。
• Mapping the S1 and S1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents
  作者：Lorenzo Cianni、Carina Lemke、Erik Gilberg、Christian Feldmann、Fabiana Rosini、Fernanda dos Reis Rocho、Jean F. R. Ribeiro、Daiane Y. Tezuka、Carla D. Lopes、Sérgio de Albuquerque、Jürgen Bajorath、Stefan Laufer、Andrei Leitão、Michael Gütschow、Carlos A. Montanari

  DOI：10.1371/journal.pntd.0007755

  日期：——

  treatment of cutaneous leishmaniasis. The synthesized compounds are dipeptidyl nitriles designed based on the most promising combinations of different moieties in P1 (ten), P2 (six), and P3 (four different building blocks). Eight compounds exhibited a Ki smaller than 20.0 nM for Cz, whereas three compounds met these criteria for LmCPB. Three inhibitors had an EC50 value of ca. 4.0 μM, thus being equipotent

  半胱氨酸蛋白酶Cruzipain被认为是治疗南美锥虫病的有效治疗靶标。设计，合成了一系列26种新化合物，并针对重组Cruzain（Cz）进行了测试，以绘制其S1 / S1´子位图。在一组四个人类半胱氨酸蛋白酶（CatB，CatK，CatL，CatS）和墨西哥利什曼原虫CPB（一组可能是治疗皮肤利什曼病的潜在靶标）上对同一系列进行了评估。合成的化合物是基于P1（十个），P2（六个）和P3（四个不同的结构单元）中不同部分最有希望的组合而设计的二肽基腈。八个化合物的Cz的Ki小于20.0 nM，而三个化合物的LmCPB符合这些标准。三种抑制剂的EC50值为ca。4.0微米 因此，根据其抗胰锥作用，与苯硝唑相当。我们的作图方法和各自的结构活性关系为治疗相关的半胱氨酸蛋白酶的特定配体-靶标相互作用提供了见识。
• Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects
  作者：Shi-Wu Chen、Yuan-Yu Gao、Ni-Ni Zhou、Jie Liu、Wen-Ting Huang、Ling Hui、Yan Jin、Yong-Xin Jin

  DOI：10.1016/j.bmcl.2011.10.024

  日期：2011.12

  In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl- 4-deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities

  为了产生具有优良生物活性和降低的毒性的化合物，合成了12个氨基甲酸酯的4'-脱甲基-4-脱氧鬼臼毒素，N-（1-氧基-1'-脱甲基-4-4-脱氧鬼臼酸）-α-氨基酸酰胺。并评估其抗增殖活性和细胞周期效应。与母体DPT或抗癌药VP-16相比，这些合成的化合物被证明对四种细胞系（A-549，HeLa，SiHa和HL-60）具有更强的亲水性，以及改善的或相当的体外细胞毒性。此外，流式细胞仪分析表明，N-（1-氧基-1'-脱甲基-4-脱氧鬼臼酸）-d -α-次甲基酰胺（15f）诱导了A-549细胞在G2 / M期的细胞周期停滞。
• Papain-Catalyzed Peptide Bond Formation: Enzyme-Specific Activation with Guanidinophenyl Esters
  作者：Roseri J. A. C. de Beer、Barbara Zarzycka、Helene I. V. Amatdjais-Groenen、Sander C. B. Jans、Timo Nuijens、Peter J. L. M. Quaedflieg、Floris L. van Delft、Sander B. Nabuurs、Floris P. J. T. Rutjes

  DOI：10.1002/cbic.201100267

  日期：2011.9.19

  Fooling with substrate recognition: Guanidinophenyl (OGp) esters were utilized as potential substrate mimetics for papain‐induced dipeptide synthesis under aqueous conditions. Surprisingly, modeling studies instead revealed unprecedented enzyme‐specific activation, applicable to nearly all amino acids.

  具有底物识别功能的傻瓜：胍基苯基（OGp）酯被用作在水性条件下木瓜蛋白酶诱导的二肽合成的潜在底物模拟物。令人惊讶的是，建模研究显示出空前的酶特异性激活作用，几乎适用于所有氨基酸。