毒理性
◉ 母乳喂养期间使用总结：一项古老研究的有限信息表明，母亲每天服用1克环丝氨酸会在乳汁中产生中等水平的药物。如果母亲需要环丝氨酸，这不是停止母乳喂养的理由，特别是如果婴儿已经超过2个月大。如果在此期间使用该药物，应监测纯母乳喂养的婴儿，如果有担忧，可能包括测量血清水平以排除毒性。
◉ 对母乳喂养婴儿的影响：在对5名服用口服环丝氨酸250毫克，每日4次的母亲的母乳喂养婴儿（年龄未说明）中，未观察到不良反应。
环丝氨酸作为多重药物治疗方案的一部分，用于治疗5名多药耐药结核病的妇女，其中4人在怀孕和产后期间使用，另一人仅在产后使用。婴儿接受了母乳喂养（喂养程度和持续时间未说明）。在1.25岁、1.8岁、3.9岁、4.6岁和5.5岁时，这些儿童除了一个有轻微语言迟缓，另一个有多动症外，都表现出了正常的发育。
◉ 对泌乳和母乳的影响：截至修订日期，未找到相关的已发布信息。
◉ Summary of Use during Lactation:Limited information from an old study indicates that maternal doses of cycloserine of 1 gram daily produce moderate levels in milk. If cycloserine is required by the mother, it is not a reason to discontinue breastfeeding, especially if the infant is older than 2 months. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.
◉ Effects in Breastfed Infants:No adverse effects were noted in 5 in breastfed infants (ages not stated) whose mothers were taking oral cycloserine 250 mg 4 times daily.
Cycloserine was used as part of multi-drug regimens to treat 5 women with multidrug-resistant tuberculosis, 4 throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 1.25, 1.8, 3.9, 4.6 and 5.5 years, the children were developing normally except for a mild speech delay in one and hyperactivity in another.
◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.
来源:Drugs and Lactation Database (LactMed)
