trimethyl-[[(2S,3S,4R)-3,4,5-tris(trimethylsilyloxy)oxolan-2-yl]methoxy]silane | 58117-32-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trimethyl-[[(2S,3S,4R)-3,4,5-tris(trimethylsilyloxy)oxolan-2-yl]methoxy]silane
• CAS: 58117-32-1
• 化学式: C₁₇H₄₂O₅Si₄
• 分子量: 438.859
• InChiKey: LDFPXMNJVPETIY-PMRDEQMMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.85
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one 9-O-[α-L-arabinofuranosyl-(1->6)-β-D-glucopyranoside] 、 trimethylsilylimidazole 在 盐酸 、 吡啶 、 L-半胱氨酸甲酯盐酸盐 作用下， 以 1,4-二氧六环 、 水 、 吡啶 为溶剂， 反应 6.5h， 生成 1,2,3,4,6-戊-三甲基硅烷基吡喃葡萄糖 、 trimethyl-[[(2S,3S,4R)-3,4,5-tris(trimethylsilyloxy)oxolan-2-yl]methoxy]silane
  参考文献：
  名称：

  Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa

  摘要：

  By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5 mu M Trolox equivalents at the concentration of 2.0 mu M. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4 mu M. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.025

文献信息

• Sorangiadenosine, a New Sesquiterpene Adenoside from the Myxobacterium <i>Sorangium cellulosum</i>
  作者：Jong-Woong Ahn、Kyoung Hwa Jang、Soon-Chun Chung、Ki-Bong Oh、Jongheon Shin

  DOI：10.1021/ol800061h

  日期：2008.3.1

  Sorangiadenosine (1), a novel nucleoside possessing a bicyclic, eudesmane-type sesquiterpene as an auxiliary component, was isolated from the culture broth of the gliding bacterium Sorangium cellulosum KM1003, collected from Korean soil. The chemical structure of this compound was determined by combined spectroscopic and chemical analyses. The new compound exhibited. moderate antibacterial activity against a wide range of bacterial strains.
• Antioxidant activity of a new C-glycosylflavone from the leaves of Ficus microcarpa
  作者：Phan Van Kiem、Nguyen Xuan Cuong、Nguyen Xuan Nhiem、Vu Kim Thu、Ninh Khac Ban、Chau Van Minh、Bui Huu Tai、Truong Nam Hai、Sang Hyun Lee、Hae Dong Jang、Young Ho Kim

  DOI：10.1016/j.bmcl.2010.12.025

  日期：2011.1

  By bioactive-guided fractionation of methanol extract of the Ficus microcarpa leaves, one new C-glucosylflavone, ficuflavoside (1), one new megastigmane glycoside, ficumegasoside (8), and twelve known compounds including flavonoids (2-6), phenylpropanoids (7), megastigmanes (9-11) and sterol derivatives (12-14) were isolated. Their chemical structures were elucidated by mass, 1D, and 2D NMR spectroscopies. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity methods. Compounds 1-6 exhibited potent antioxidant activities of 6.6-9.5 mu M Trolox equivalents at the concentration of 2.0 mu M. The results indicated 2, 3, and 5 having meaningful reducing capacity of copper (I) ions concentration of 6.1-8.4 mu M. (C) 2010 Elsevier Ltd. All rights reserved.