2-(5-tetrazolyl)-5-chloro-1,3-oxazolo-[4,5-h]quinoline | 88362-80-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(5-tetrazolyl)-5-chloro-1,3-oxazolo-[4,5-h]quinoline
• 英文别名: 5-Chloro-2-(2H-tetrazol-5-yl)[1,3]oxazolo[4,5-h]quinoline；5-chloro-2-(2H-tetrazol-5-yl)-[1,3]oxazolo[4,5-h]quinoline
• CAS: 88362-80-5
• 化学式: C₁₁H₅ClN₆O
• 分子量: 272.653
• InChiKey: VQOZBKAQULYHPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-cyano-5-chloro-1,3-oxazolo-[4,5-h]quinoline 在 ammonium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(5-tetrazolyl)-5-chloro-1,3-oxazolo-[4,5-h]quinoline
  参考文献：
  名称：

  Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents

  摘要：

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯并二氮杂环化合物，其中喹啉化合物的化学式为：##STR1##及其盐，其中R.sub.1和R.sub.2独立地是氢、较低烷基、卤素、三氟甲基、氨基、较低烷基氨基、较低酰胺基、氰基、芳基、芳基/较低烷基、硝基、较低炔基、较低烯基、较低烷基亚砜基、较低烷基磺酰基、较低烷氧羰基、羧基、较低烷氧基、较低脂酰基或较低烯酰基，Y为氧、硫、氮或R.sub.3 N，其中R.sub.3为氢、较低烷基、烯基、炔基、芳基、芳基烷基、酰基、氨基烷基或羧基烷基，Z为氧、硫或氮，X为氰基、羰基烷氧基、羧基、甲氧基亚胺基、四唑基、羰基烷氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘，和/或用作制备用于治疗哮喘的化合物的中间体。

  公开号：

  US04522947A1

文献信息

• 2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents
  申请人：USV Pharmaceutical Corp.

  公开号：US04563463A1

  公开（公告）日：1986-01-07

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formulae: ##STR1## and salts thereof, wherein R is hydrogen, acyl, carboethoxy,(3-methoxyphen)acetyl,(2-phenyl)propionyl, dimethylcarbamoyl or methyl, R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxy, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯二氮杂环化合物，其中喹啉化合物的化学式为：##STR1##及其盐，其中R为氢，酰基，羧乙氧基，(3-甲氧基苯)乙酰基，(2-苯基)丙酰基，二甲基氨基甲酰基或甲基，R.sub.1和R.sub.2分别为氢，低碳基，卤素，三氟甲基，氨基，低碳基氨基，低酰胺基，氰基，芳基，芳基/低碳基烯基，硝基，低炔基，低烯基，低碳基亚砜基，低碳基磺酰基，低碳氧羰基，羧基，低碳氧基，低碳酰基或低碳烯酰基，Y为氧，硫，氮或R.sub.3 N，其中R.sub.3为氢，低碳基，烯基，炔基，芳基，芳基烷基，酰基，氨基烷基或羧基烷基，Z为氧，硫或氮，X为氰基，羧酰氧基，羧基，甲氧基亚硝基，四唑基，羧酰氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘，和/或作为制备用于治疗哮喘的化合物的中间体。
• Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents
  申请人：USV Pharmaceutical Corporation

  公开号：US04522947A1

  公开（公告）日：1985-06-11

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯并二氮杂环化合物，其中喹啉化合物的化学式为：##STR1##及其盐，其中R.sub.1和R.sub.2独立地是氢、较低烷基、卤素、三氟甲基、氨基、较低烷基氨基、较低酰胺基、氰基、芳基、芳基/较低烷基、硝基、较低炔基、较低烯基、较低烷基亚砜基、较低烷基磺酰基、较低烷氧羰基、羧基、较低烷氧基、较低脂酰基或较低烯酰基，Y为氧、硫、氮或R.sub.3 N，其中R.sub.3为氢、较低烷基、烯基、炔基、芳基、芳基烷基、酰基、氨基烷基或羧基烷基，Z为氧、硫或氮，X为氰基、羰基烷氧基、羧基、甲氧基亚胺基、四唑基、羰基烷氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘，和/或用作制备用于治疗哮喘的化合物的中间体。
• Imidazo quinoline compounds useful as anti-allergy agents
  申请人：USV Pharmaceutical Corp.

  公开号：US04656281A1

  公开（公告）日：1987-04-07

  The quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or intermediates in the preparation of compounds useful for treating asthma.

  喹啉化合物的公式为：##STR1##及其盐，其中R.sub.1和R.sub.2独立地为氢、低烷基、卤素、三氟甲基、氨基、低烷基氨基、低酰胺基、氰基、芳基、芳基/低烷基、硝基、低炔基、低烯基、低烷基亚磺酰基、低烷基磺酰基、低烷氧羰基、羧基、低烷氧基、低烷酰基或低烯酰基，Y为氮或R.sub.3 N，其中R.sub.3为氢、低烷基、烯基、炔基、芳基、芳基烷基、酰基、氨基烷基或羧基烷基，Z为氮，X为氰基、碳酰氧基、羧基、甲酰羟肟基、四唑基、碳酰氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于治疗哮喘和/或用于制备用于治疗哮喘的化合物的中间体。
• Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents
  申请人：USV Pharmaceutical Corporation

  公开号：US04698346A1

  公开（公告）日：1987-10-06

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R.sub.3 N wherein R.sub.3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的1,2-；1,3-；和1,4-苯并二氮杂环，其中喹啉化合物的式子为：##STR1##以及其盐，其中R.sub.1和R.sub.2独立地为氢，低级烷基，卤素，三氟甲基，氨基，低级烷基氨基，低酰基氨基，氰基，芳基，芳基/低级烷基，硝基，低级炔基，低级烯基，低级烷基亚砜基，低级烷基磺酰基，低级烷氧羰基，羧基，低级烷氧基，低级烷酰基，或低级烯酰基，Y为氧，硫，氮或R.sub.3 N，其中R.sub.3为氢，低级烷基，烯基，炔基，芳基，芳基烷基，酰基，氨基烷基或羧基烷基，Z为氧，硫或氮，X为氰基，羧基烷氧基，羧基，甲酰氧肟基，四唑基，羧基烷氧基烷基或羧基烷基，m为0或1，可用作药物，特别是用于哮喘的治疗，和/或作为用于治疗哮喘的化合物的中间体。
• New quinoline and related compounds useful as anti-allergy agents
  申请人：RORER INTERNATIONAL (OVERSEAS) INC.

  公开号：EP0090360A2

  公开（公告）日：1983-10-05

  New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: and salts thereof, wherein R1 and R2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl, Y is oxygen, sulfur, nitrogen or R3N wherein R3 is hydrogen, lower alkyl, alkenyl, alkynyl, aryl, aralkyl, acyl, aminoalkyl, or carboxyalkyl, Z is oxygen, sulfur or nitrogen, X is cyano, carbalkoxyl, carboxyl, formyloximino, tetrazolyl, carbalkoxyalkyl or carboxyalkyl, and m is 0 or 1, are useful as medicinals, especially for treatment of asthma, and/or as intermediates in the preparation of compounds useful for treating asthma.

  新的喹啉化合物，以及相应的 1，2-；1，3-；和 1，4-苯并二氮杂卓，这些喹啉化合物的式为 及其盐类，其中 R1和R2独立地为氢、低级烷基、卤代、三氟甲基、氨基、低级烷基氨基、低级酰氨基、氰基、芳基、芳基/低级亚烷基、硝基、低级炔基、低级烯基、低级烷基亚磺酰基、低级烷基磺酰基、低级烷氧基羰基、低级羧酰基、低级烷氧基羰基、低级烷氧基羰基、低级烷氧基羰基、Y 是氧、硫、氮或 R3N，其中 R3 是氢、低级烷基、烯基、炔基、芳基、芳烷基、酰基、氨基烷基或羧基、 Z为氧、硫或氮，X为氰基、碳烷氧基、羧基、甲酰亚胺基、四唑基、碳烷氧基烷基或羧基，m为0或1，可用作药物，特别是治疗哮喘的药物，和/或用作制备治疗哮喘的化合物的中间体。