L-精氨酸-Alpha-酮戊二酸盐 | 16856-18-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 精氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-精氨酸-Alpha-酮戊二酸盐
• 中文别名: L-精氨酸Α-酮戊二酸；L-精氨酸ALPHA-酮戊二酸；L-精氨酸-α-酮戊二酸盐；L-精氨酸alpha-酮戊二酸盐；Α-酮戊二酸精氨酸盐；L-精氨酸 alpha-酮戊二酸盐；L-精氨酸 α-酮戊二酸盐；L-精氨酸 ALPHA-酮戊二酸(1:1)；L-精氨酸・α-酮戊二酸盐1:1混合物；L-精氨酸酮戊二酸盐(1:1)；α-酮戊二酸精氨酸盐(1:1)；L-精氨酸.α-酮戊二酸盐(1:1)；L-精氨酸-α-酮戊二酸(1:1)；L-精氨酸α-酮戊二酸盐 1:1；L-精氨酸-α-酮戊二酸；L-精氨酸-alpha-酮戊二酸盐
• 英文名称: α-ketoglutaratic acid L-arginine salt
• 英文别名: α-ketoglutaric acid L-arginine salt；L-arginine α-ketoglutarate；L-arginine-α-ketoglutarate；L-arginine alpha-ketoglutarate；Arginine alpha-ketogluturate；L-Arginine 2-oxoglutarate；(2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid;2-oxopentanedioic acid
• CAS: 16856-18-1；5256-76-8
• 化学式: C₅H₆O₅*C₆H₁₄N₄O₂
• 分子量: 320.302
• InChiKey: PGRNZHOQVAPMFX-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.04
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  219
• 氢给体数：
  6
• 氢受体数：
  9

安全信息

• 海关编码：
  2925290090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

用途：用于增强体质。

反应信息

• 作为产物：
  描述：

  L-精氨酸 、 dimethyl 2,2-dichloro-1,5-pentanedioate 以 水 为溶剂， 生成 L-精氨酸-Alpha-酮戊二酸盐
  参考文献：
  名称：

  Process for preparation of alpha-ketoglutaric acid

  摘要：

  一种制备α-酮戊二酸的方法，适用于制备L-精氨酸α-酮戊二酸1:1和2:1，包括以下步骤：(a)将二氯乙酸甲酯和丙烯酸甲酯与甲氧基钠反应，得到二甲基2,2-二氯戊二酸酯；(b)将步骤(a)中得到的二甲基2,2-二氯戊二酸酯与氢氧化物溶液反应，得到粗α-酮戊二酸水溶液；(c)纯化粗α-酮戊二酸水溶液，得到纯化的α-酮戊二酸水溶液；(d)通过加水调节纯化的α-酮戊二酸水溶液的浓度，从而获得纯化的α-酮戊二酸水溶液的收率约为75%。本发明的方法避免了使用大量的有机溶剂，具有显著的高收率，能够实现低成本的大规模生产并缩短生产时间。

  公开号：

  US20120095261A1

文献信息

• [EN] METHODS AND COMPOSITIONS INVOLVING (S)-BUCINDOLOL<br/>[FR] MÉTHODES ET COMPOSITIONS METTANT EN JEU DU (S)-BUCINDOLOL
  申请人：ARCA DISCOVERY INC

  公开号：WO2010014263A1

  公开（公告）日：2010-02-04

  Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of its R-stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also disclosed are methods of treating a patient that involve administering to the patient a therapeutically effective amount of a composition of the present invention. Formula (I).

  本发明公开了几乎不含其R-立体异构体的布辛多洛。还公开了包括几乎不含其R-立体异构体或其药学上可接受的盐以及药学上可接受的载体的布辛多洛制剂。还公开了治疗患者的方法，该方法涉及向患者投与本发明组合物的治疗有效量。公式（I）。
• Process for preparation of L-Arginine alpha-ketoglutarate 1:1 and 2:1
  申请人：Zhang Guoji

  公开号：US20120095260A1

  公开（公告）日：2012-04-19

  A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.

  一种制备α-酮戊二酸、L-精氨酸α-酮戊二酸1:1和2:1的方法，包括以下步骤：提供调整浓度的α-酮戊二酸水溶液；将一个当量的固体L-精氨酸加入α-酮戊二酸水溶液中；搅拌并在控制温度下进行反应；得到pH约为3˜4的L-精氨酸α-酮戊二酸1:1溶液或pH约为6.5˜7的L-精氨酸α-酮戊二酸2:1溶液；并通过喷雾干燥获得最终产品L-精氨酸α-酮戊二酸1:1或2:1。该过程的产率为L-精氨酸α-酮戊二酸1:1约为94％，L-精氨酸α-酮戊二酸2:1约为97％。消除了大量溶剂，缩短了反应时间，但提高了产率，因此通过反应器实现了成本和时间上的大规模生产。
• Process for preparation of l-arginine alpha-ketoglutarate 1:1 and 2:1
  申请人：Zhang Guoji

  公开号：US20140187815A1

  公开（公告）日：2014-07-03

  A process for preparation of α-ketoglutaric acid, L-arginine α-ketoglutarate 1:1 and 2:1, comprising the steps of: providing a α-ketoglutaratic acid aqueous solution at an adjusted concentration; adding one equivalent mole of solid L-arginine to the α-ketoglutaratic acid aqueous solution; stirring and allowing reaction under a controlled temperature; (e) obtaining a resulting L-arginine α-ketoglutarate 1:1 solution with a pH of approximately 3˜4 or L-arginine α-ketoglutarate 2:1 solution with a pH of approximately 6.5˜7; and obtaining a final product of L-arginine α-ketoglutarate 1:1 or 2:1 through spay drying. The yield of the final product is approximately 94% for L-arginine α-ketoglutarate 1:1 and 97% for L-arginine α-ketoglutarate 2:1 through the process. Large amount of solvents is eliminated and reaction time is shortened but the yield is increased, hence realizing mass production through reactor in a cost and time effective manner.

  一种制备α-酮戊二酸、L-精氨酸α-酮戊二酸1:1和2:1的方法，包括以下步骤：提供调整浓度的α-酮戊二酸水溶液；向α-酮戊二酸水溶液中加入等当量的固体L-精氨酸；在控制温度下搅拌和反应；获得pH约为3~4的L-精氨酸α-酮戊二酸1:1溶液或pH约为6.5~7的L-精氨酸α-酮戊二酸2:1溶液；通过喷雾干燥获得最终的L-精氨酸α-酮戊二酸1:1或2:1产品。通过该过程，L-精氨酸α-酮戊二酸1:1的产率约为94％，L-精氨酸α-酮戊二酸2:1的产率约为97％。该方法消除了大量溶剂，缩短了反应时间，但提高了产率，从而以成本和时间有效的方式通过反应器实现大规模生产。
• COMPOSITIONS COMPRISING UNSATURATED FATTY ACIDS AND NITRIC OXIDE RELEASING COMPOUNDS AND USE THEREOF FOR ENHANCING COGNITIVE AND RELATED FUNCTIONS
  申请人：Nestec S.A.

  公开号：EP3058942A1

  公开（公告）日：2016-08-24

  Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals.

  由一种或多种不饱和脂肪酸和一种或多种一氧化氮释放化合物组成的组合物，以及使用这种组合物增强认知功能、减少或防止社会交往能力下降、减少或防止与年龄相关的行为变化、提高可训练性、保持最佳脑功能、促进学习和记忆、减少记忆丧失、延缓脑衰老、预防或治疗中风、预防或治疗动物痴呆症的方法 优选地，这些组合物是有助于增强人类和伴侣动物认知功能的食品组合物。
• PERFORMANCE ENHANCING COMPOSITION
  申请人：HeartBeet Ltd.

  公开号：EP3159000A1

  公开（公告）日：2017-04-26

  The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

  通过向哺乳动物施用无毒量的硝酸盐和/或亚硝酸盐，可以提高哺乳动物的运动表现，表现为运动期间摄氧量（VO2）的降低。可提供液体、半固体和固体零食和食品以及营养补充剂，如运动饮料。