L-组氨酸酰胺盐酸盐 | 71666-95-0

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 天然氨基酸及其衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-组氨酸酰胺盐酸盐
• 中文别名: L-组胺酰胺二盐酸盐
• 英文名称: H-His-NH2.2HCl
• 英文别名: (2S)-2-amino-3-(1H-imidazol-5-yl)propanamide;dihydrochloride
• CAS: 71666-95-0
• 化学式: C6H12Cl2N4O
• 分子量: 227.09
• InChiKey: CRBYFJCXMZNLTO-XRIGFGBMSA-N

物化性质

• 熔点：
  257-258 °C
• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.39
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.8
• 氢给体数：
  5
• 氢受体数：
  3

安全信息

• WGK Germany：
  3
• 海关编码：
  2933290090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Cycloalkylamides and their therapeutic applications
  申请人：——

  公开号：US20040209858A1

  公开（公告）日：2004-10-21

  The present invention relates to the use of compounds of formula (I) 1 for the treatment of a variety of disorders including, but not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.

  本发明涉及使用式(I)1的化合物治疗多种疾病，包括但不限于癫痫、双相情感障碍、精神障碍、偏头痛、疼痛、神经保护和运动障碍。
• Neue Derivate des BPTI(basic pancreatic trypsin-inhibitor), Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
  申请人：BAYER AG

  公开号：EP0001774A1

  公开（公告）日：1979-05-16

  Denvate des Kallikrein-Trypsin Inlnbitors und insbeson dere des Kallikrein-Trypsin-Inhibitors aus Rinderorganen (BPTI = basic pancreatic trypsin inhibitor Kunitz genannt) werden aus BPTI oder seinen Derivaten mit freien Carboxylgruppen durch Umsetzung mit nucleophilen Aminoverbindungen in Gegenwart von Carbodiimiden erhalten, gegebenenfalls anschließend desaminiert und/oder in Azoderivate übergeführt. Die BPTI-Derivate werden als Arzneimittel verwendet

  在碳化二亚胺的存在下，通过与亲核氨基化合物反应，可从 BPTI 或其带有游离羧基的衍生物中获得胰凝乳蛋白酶-胰蛋白酶抑制剂的变性物，特别是牛器官中的胰凝乳蛋白酶-胰蛋白酶抑制剂（BPTI = 碱性胰蛋白酶抑制剂 Kunitz），必要时还可随后脱氨基和/或转化为偶氮衍生物。BPTI 衍生物可用作药物
• CYCLOALKYLAMIDES AND THEIR THERAPEUTIC USE AS ANTIEPILEPTIC AND ANTICONVULSANT
  申请人：ABBOTT LABORATORIES

  公开号：EP1606244A2

  公开（公告）日：2005-12-21
• [EN] CYCLOALKYLAMIDES AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] CYCLOALKYLAMIDES ET UTILISATIONS THERAPEUTIQUES ASSOCIEES
  申请人：ABBOTT LAB

  公开号：WO2004037769A2

  公开（公告）日：2004-05-06

  The present invention relates to the use of compounds of formula (I)for the treatment of a variety of disorders including, bu t not limited to, epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, neuroprotection, and movement disorders.
• [EN] DYE COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICES THEREFOR<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE GLYCOSYLIQUE ET UN ALDÉHYDE PARTICULIER OU UNE IMINE PARTICULIÈRE, PROCÉDÉ DE COLORATION ET DISPOSITIFS S'Y RAPPORTANT
  申请人：OREAL

  公开号：WO2013045704A2

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: * a compound of the iridoid family of formula (I) below, or a plant extract comprising the same: in which R1: hydrogen, methyl, hydroxymethyl, aldehyde; -CO2R4 in which R4: hydrogen, C1-C2 alkyl; sugar; R2: a hydrogen atom, a hydroxyl radical, sugar radical; R3: hydrogen, hydroxyl, alkyloxy; R: sugar radical (aldose or derivative); integer ranging from 1 to 5; the compound(s) of formula (I) having optionally undergone a preliminary step consisting in replacing the radical R with a hydrogen atom, performed using an enzyme; ** at least one aldehyde or imine compound of formulae (i) and (ii), and also oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function: with n equal to 0 or 1; X: O, NR'1; A: COOH, optionally substituted aryl, cationic or non-cationic, saturated or unsaturated 5- or 6-membered heterocycle, comprising one or two heteroatoms, optionally substituted, alkyl, alkenyl; A2 divalent alkylene; the compounds possibly being, in the case of aldehydes, in acetal or hemiacetal form. The invention also relates to a process using such a composition, and also to multi-compartment devices.