L-赖氨酰-L-赖氨酸二盐酸盐 | 52123-30-5

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 赖氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-赖氨酰-L-赖氨酸二盐酸盐
• 英文名称: L-lysyl-L-lysine dihydrochloride
• 英文别名: (2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoic acid;dihydrochloride
• CAS: 52123-30-5
• 化学式: C12H28Cl2N4O3
• mdl: MFCD00058272
• 分子量: 347.28
• InChiKey: LXQFWEBCTJENGB-BZDVOYDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.97
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  145
• 氢给体数：
  7
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S22,S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3

文献信息

• [EN] GLUCOSE-RESPONSIVE INSULIN CONJUGATES<br/>[FR] CONJUGUÉS D'INSULINE SENSIBLES AU GLUCOSE
  申请人：MERCK SHARP & DOHME

  公开号：WO2020247297A1

  公开（公告）日：2020-12-10

  Glucose-responsive insulin conjugates that contain one or more linear oligomer sugar cluster are provided. Such insulin conjugates that may display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose, even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule.

  提供含有一个或多个线性寡聚糖团簇的葡萄糖响应胰岛素共轭物。这种胰岛素共轭物可能表现出对体内葡萄糖或α-甲基甘露糖等糖类的系统浓度响应的药代动力学（PK）和/或药效动力学（PD）特性，即使在向需要的受试者施用时，也无需外源多价糖结合分子。
• Cell-specific glycopeptide ligands
  申请人：Merck & Co., Inc.

  公开号：EP0063373A1

  公开（公告）日：1982-10-27

  Cell-specific ligands comprising conjugates of saccharides and amino acids or peptides are synthesized from amino acids such as ornithine, lysine, peptides such as dilysine, diornithine or oligolysine and selected saccharides having reactive functional groups protected by appropriate blocking groups. Such glycopeptides include e.g. N2-N2, N6-bis[3-(a-D-mannopyranosylthio)propionyl]-L-lysyl} -N6- [3-(a-D-mannopyranosylthiolpropionyl]-L-lysine (5). Those compounds are useful as tissue specific substances, which when coupled with bioactive materials through metabolizable or hydrolyzable linkages, deliver such bioactive materials to the selected site. In this manner, antiinflammatory drugs such as dexamethasone are linked through a metabolizable or hydrolyzable linkage and on administration to an animal suffering from inflammatory disease carries the drug to the site of inflammation for intracellular release.

  由糖和氨基酸或肽的共轭物组成的细胞特异性配体是由氨基酸（如鸟氨酸、赖氨酸）、肽（如二赖氨酸、二鸟氨酸或低聚赖氨酸）和具有活性官能团并受适当阻断基团保护的精选糖合成的。这类糖肽包括如 N2-N2，N6-双[3-（a-D-吡喃甘露糖硫基）丙酰基]-L-赖氨酸}-N6-[3-（a-D-吡喃甘露糖硫基）丙酰基]-L-赖氨酸（5）。这些化合物是有用的组织特异性物质，当通过可代谢或可水解的连接与生物活性物质结合时，可将这些生物活性物质输送到选定的部位。通过这种方式，地塞米松等抗炎药物通过可代谢或可水解连接，在给患有炎症疾病的动物用药时，可将药物带到炎症部位进行细胞内释放。
• Attachment of compounds to polymeric particles using carbamoylonium compounds
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0308235A2

  公开（公告）日：1989-03-22

  Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having carboxyl groups on the outer surfaces. Such reactive compounds include biologically reactive species, such as enzymes, polypeptides and proteins. This attachment is carried out using carbamoylonium compounds which react with the carboxyl groups to form intermediate reactive groups which then react with the amino or sulfhydryl groups to form a covalent linkage between particle and reactive compound.

  通过将含有活性氨基或巯基的活性化合物共价连接到外表面具有羧基的聚合物颗粒上，可以制备出用于诊断测试、亲和层析、酶反应和免疫测定的有用材料。这类活性化合物包括生物活性物质，如酶、多肽和蛋白质。这种连接是利用氨基甲酰基化合物进行的，氨基甲酰基化合物与羧基反应形成中间活性基团，然后与氨基或巯基反应，在颗粒和活性化合物之间形成共价连接。
• Method for the inhibition of cell-cell and cell substratum interactions by the blocking of carbohydrate-carbohydrate interactions
  申请人：The Biomembrane Institute

  公开号：EP0380084A2

  公开（公告）日：1990-08-01

  Methods for the inhibition of cell-cell and cell-­substratum interactions by the blocking of carbohydrate-­carbohydrate interactions are disclosed. Inhibition of cell-­cell and cell-substratum interactions by the methods of the present invention permit the inhibition of a variety of biological phenomena, including metastases, mammalian diseases that are microbial in origin, mammalian fertilization, and plant pathologies. Suitable agents for blocking carbohydrate-­carbohydrate interactions include saccharides, glycocon­jugates, and antibodies directed against carbohydrate determinants.

  本发明公开了通过阻断碳水化合物-碳水化合物相互作用来抑制细胞-细胞和细胞-基质相互作用的方法。通过本发明的方法抑制细胞-细胞和细胞-基质之间的相互作用，可抑制多种生物现象，包括转移、源于微生物的哺乳动物疾病、哺乳动物受精和植物病理学。阻断碳水化合物-碳水化合物相互作用的合适制剂包括糖类、糖类共轭物和针对碳水化合物决定因子的抗体。
• Dicarboxylic acid oxidation products
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0468590A2

  公开（公告）日：1992-01-29

  What is disclosed is a dicarboxylic acid oxidation product of an immunologically reactive mono- or a polysaccharide having vicinal diols.

  所公开的是一种具有免疫活性的单糖或多糖的二羧酸氧化产物，该单糖或多糖具有邻位二醇。