sinulariol L | 1329684-29-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: sinulariol L
• 英文别名: (1S,4E,6S,7R,10Z,14S)-11-(hydroxymethyl)-1,7-dimethyl-4-propan-2-yl-15-oxabicyclo[12.1.0]pentadeca-4,10-diene-6,7-diol
• CAS: 1329684-29-8
• 化学式: C₂₀H₃₄O₄
• 分子量: 338.488
• InChiKey: CTMXVBYCUXIQDP-OOPIJYLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  73.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sinulariol L 、 (S)-(+)-alpha-甲氧基苯乙酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以1.7 mg的产率得到
  参考文献：
  名称：

  Sinulariols A–S, 19-oxygenated cembranoids from the Chinese soft coral Sinularia rigida

  摘要：

  Chemical examination of a Chinese soft coral Sinularia rigida resulted in the isolation and characterization of 19 new cembrane-type diterpenoids, designated as sinulariols A-S (1-19). Their structures were determined on the basis of extensive spectroscopic (2D NMR, IR, and MS) analysis in association with modified Mosher's method. All compounds featured unusual 19-oxygenated functionalities, which are rarely found from cembranoid family. The biogenetic transformation of the isolated compounds is postulated. Part of the isolated cembranoids showed significant anti-fouling activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.06.029

文献信息

• Sinulariols A–S, 19-oxygenated cembranoids from the Chinese soft coral Sinularia rigida
  作者：Daowan Lai、Yongxin Li、Minjuan Xu、Zhiwei Deng、Leen van Ofwegen、Peiyuan Qian、Peter Proksch、Wenhan Lin

  DOI：10.1016/j.tet.2011.06.029

  日期：2011.8

  Chemical examination of a Chinese soft coral Sinularia rigida resulted in the isolation and characterization of 19 new cembrane-type diterpenoids, designated as sinulariols A-S (1-19). Their structures were determined on the basis of extensive spectroscopic (2D NMR, IR, and MS) analysis in association with modified Mosher's method. All compounds featured unusual 19-oxygenated functionalities, which are rarely found from cembranoid family. The biogenetic transformation of the isolated compounds is postulated. Part of the isolated cembranoids showed significant anti-fouling activity. (C) 2011 Elsevier Ltd. All rights reserved.