(E)-1-(4-phenyl-2-styrylquinolin-3-yl)ethanone | 1318193-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (E)-1-(4-phenyl-2-styrylquinolin-3-yl)ethanone
• 英文别名: 1-[4-phenyl-2-[(E)-2-phenylethenyl]quinolin-3-yl]ethanone
• CAS: 1318193-33-7
• 化学式: C₂₅H₁₉NO
• 分子量: 349.432
• InChiKey: KSYREOCUAHRFMC-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲醛 在 硅酸四乙酯 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 (E)-1-(4-phenyl-2-styrylquinolin-3-yl)ethanone
  参考文献：
  名称：

  A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions

  摘要：

  A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C-N elimination in situ. A one-pot procedure for this addition-elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.

  DOI：

  10.1021/jo2008934

文献信息

• A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions
  作者：Yizhe Yan、Kun Xu、Yang Fang、Zhiyong Wang

  DOI：10.1021/jo2008934

  日期：2011.8.19

  A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C-N elimination in situ. A one-pot procedure for this addition-elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.