dimethyl-4-{[1,3-benzodioxol-5-yl][4-(dimethylamino)phenyl]methyl}aniline | 6310-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: dimethyl-4-{[1,3-benzodioxol-5-yl][4-(dimethylamino)phenyl]methyl}aniline
• 英文别名: benzo[1,3]dioxol-5-yl-bis-(4-dimethylamino-phenyl)-methane；Benzo[1,3]dioxol-5-yl-bis-(4-dimethylamino-phenyl)-methan；4-[1,3-benzodioxol-5-yl-[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
• CAS: 6310-52-7
• 化学式: C₂₄H₂₆N₂O₂
• 分子量: 374.483
• InChiKey: AFNKGCCBAXFYEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  胡椒醛 、 N,N-二甲基苯胺 在 五氯化铌 作用下， 反应 2.0h， 以88%的产率得到dimethyl-4-{[1,3-benzodioxol-5-yl][4-(dimethylamino)phenyl]methyl}aniline
  参考文献：
  名称：

  An efficient and convenient protocol for the synthesis of diaminotriarylmethanes

  摘要：

  A novel and efficient procedure was developed for the preparation of diaminotriarylmethanes through the Baeyer condensation of aromatic aldehydes and N,N-dimethylaniline or N,N-diethylaniline in the presence of niobium chloride under solvent-free conditions. This approach offers several advantages, such as short reaction time, high yields, low cost, and mild reaction conditions.

  DOI：

  10.1007/s00706-011-0461-2

文献信息

• Votocek; Jelinek, Chemische Berichte, 1907, vol. 40, p. 409
  作者：Votocek、Jelinek

  DOI：——

  日期：——
• Reddy, Ch Sanjeeva; Nagaraj; Srinivas, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 2, p. 248 - 254
  作者：Reddy, Ch Sanjeeva、Nagaraj、Srinivas、Reddy

  DOI：——

  日期：——
• Liebermann, Chemische Berichte, 1903, vol. 36, p. 2919
  作者：Liebermann

  DOI：——

  日期：——
• An efficient and convenient protocol for the synthesis of diaminotriarylmethanes
  作者：Jun-Tao Hou、Jian-Wu Gao、Zhan-Hui Zhang

  DOI：10.1007/s00706-011-0461-2

  日期：2011.5

  A novel and efficient procedure was developed for the preparation of diaminotriarylmethanes through the Baeyer condensation of aromatic aldehydes and N,N-dimethylaniline or N,N-diethylaniline in the presence of niobium chloride under solvent-free conditions. This approach offers several advantages, such as short reaction time, high yields, low cost, and mild reaction conditions.