5-bromo-2-methyl-6-quinolinol hydrobromide | 475682-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-bromo-2-methyl-6-quinolinol hydrobromide
• 英文别名: hydrobromide salt of 5-bromo-2-methyl-6-quinolinol；5-bromo-2-methyl-6-quinolinol, hydrobromide salt；5-Bromo-2-Methyl-6-Quinolinol Hydrobromide；5-bromo-2-methylquinolin-6-ol;hydrobromide
• CAS: 475682-40-7
• 化学式: BrH*C₁₀H₈BrNO
• 分子量: 318.996
• InChiKey: AWXQNMQOOCQHQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.59
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-bromo-2-methyl-6-quinolinol hydrobromide 在 Amberlyst A-21 ion-exchange resine 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以100%的产率得到5-溴-2-甲基-6-喹啉醇
  参考文献：
  名称：

  [EN] ANTIDEPRESSANT ARYLPIPERAZINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS
  [FR] DERIVES ARYLPIPERAZINES ANTIDEPRESSEURS DE BENZODIOXANES A FUSION HETEROCYCLIQUE

  摘要：

  公式I的化合物对治疗抑郁症（包括但不限于重性抑郁障碍、儿童抑郁症和心境恶劣障碍）、焦虑症、恐慌障碍、创伤后应激障碍、经前期情感障碍（也称为经前综合征）、注意力缺陷障碍（伴有和不伴有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖、厌食症和暴食症等进食障碍、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病方面具有用处。

  公开号：

  WO2004024731A1
• 作为产物：
  描述：

  5-bromo-6-methoxy-2-methylquinoline 在 乙酸乙酯 作用下， 以 氢溴酸 为溶剂， 反应 9.0h， 以to give 34.9 g (92%) of the title compound as a brown solid的产率得到5-bromo-2-methyl-6-quinolinol hydrobromide
  参考文献：
  名称：

  Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans

  摘要：

  公式I:1的化合物可用于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性抑郁症）、焦虑症、恐慌症、创伤后应激障碍、月经前失调症（也称为经前综合症）、注意力缺陷多动障碍（有或没有多动症）、强迫症、社交焦虑症、广泛性焦虑症、肥胖症、饮食失调如厌食症和贪食症、潮红、可卡因和酒精成瘾、性功能障碍及相关疾病的治疗。

  公开号：

  US20040142926A1

文献信息

• [EN] ANTIDEPRESSANT INDOLEALKYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXAN METHYLAMINES<br/>[FR] DERIVES INDOLEALKYLE D'HETEROCYCLE DE BENZODIOXAN FUSIONNES METHYLAMINES EN TANT QU'ANTIDEPRESSEURS
  申请人：WYETH CORP

  公开号：WO2004024734A1

  公开（公告）日：2004-03-25

  Compounds of the Formula: are useful for the treatment of depression ( including but not limited to major depressive disorder, childhood depression and dysthymia). Anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder ( with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  这个公式的化合物对治疗抑郁症（包括但不限于重性抑郁障碍、儿童抑郁症和慢性抑郁症）非常有用。焦虑、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也称为经前综合征）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖、厌食症、暴食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病均有一定疗效。
• Process for the synthesis of derivatives of 2, 3-dihydro-1, 4-dioxino- [2, 3-f] quinoline
  申请人：Wyeth

  公开号：US20020187983A1

  公开（公告）日：2002-12-12

  Methods of preparing compounds of Formula I 1 are provided.

  提供了制备式I1化合物的方法。
• [EN] ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS<br/>[FR] DERIVES AZAHETEROCYCLYLMETHYLIQUES DE BENZODIOXANES A FUSION HETEROCYCLIQUE A EFFET ANTIDEPRESSEUR
  申请人：WYETH CORP

  公开号：WO2004024730A1

  公开（公告）日：2004-03-25

  Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  该公式化合物用于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁和慢性抑郁）、焦虑症、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也被称为经前综合症）、注意力缺陷障碍（伴有和不伴有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖、厌食症和暴食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• [EN] ANTIDEPRESSANT PIPERIDINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS<br/>[FR] DERIVES PIPERIDINE D'HETEROCYCLE DE BENZODIOXANS FUSIONNES EN TANT QU'ANTIDEPRESSEURS
  申请人：WYETH CORP

  公开号：WO2004024733A1

  公开（公告）日：2004-03-25

  Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, chi ldhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (wit h and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  该公式化合物用于治疗抑郁症（包括但不限于重性抑郁障碍、儿童抑郁和忧郁症）、焦虑、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也称为经前综合征）、注意力缺陷障碍（有和无多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、厌食症和暴食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
  申请人：Wyeth

  公开号：US07153849B2

  公开（公告）日：2006-12-26

  Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  公式为I的化合物对于治疗抑郁症（包括但不限于重度抑郁症、儿童抑郁症和轻度抑郁症）、焦虑症、恐慌症、创伤后应激障碍、经前期不适症（也称经前综合症）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症、社交焦虑症、广泛性焦虑症、肥胖症、饮食失调如厌食症和贪食症、潮红、可卡因和酒精成瘾、性功能障碍以及相关疾病具有治疗作用。