1-(2,4-diphenyl-6-quinolinyl)ethanone | 138432-76-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2,4-diphenyl-6-quinolinyl)ethanone
• 英文别名: 1-(2,4-diphenylquinolin-6-yl)ethanone
• CAS: 138432-76-5
• 化学式: C₂₃H₁₇NO
• 分子量: 323.394
• InChiKey: QRFDMBWEJLPRMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.77
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  29.96
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  N-亚苄基-4-甲氧基苯胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯化铁 作用下， 以 乙腈 为溶剂， 反应 1.0h， 生成 1-(2,4-diphenyl-6-quinolinyl)ethanone
  参考文献：
  名称：

  Annulation reactions with iron(III) chloride: oxidation of imines

  摘要：

  Aromatic imines react with phenylacetylene or styrene in an acetonitrile solution of iron(III) chloride to give quinolines 3 or their tetrahydro derivatives 11 together with variable amounts of products 4 arising from the reduction of the imines. The initial step appears to be a one-electron oxidation to generate iron(II) and an imine radical cation. When the reactions are carried out in the presence of stoichiometric amounts of tetrachloro-p-benzoquinone (chloranil), only quinolines 3 are obtained.

  DOI：

  10.1021/jo00032a043

文献信息

• Annulation reactions with iron(III) chloride: oxidation of imines
  作者：Rino Leardini、Daniele Nanni、Antonio Tundo、Giuseppe Zanardi、Fabrizio Ruggieri

  DOI：10.1021/jo00032a043

  日期：1992.3

  Aromatic imines react with phenylacetylene or styrene in an acetonitrile solution of iron(III) chloride to give quinolines 3 or their tetrahydro derivatives 11 together with variable amounts of products 4 arising from the reduction of the imines. The initial step appears to be a one-electron oxidation to generate iron(II) and an imine radical cation. When the reactions are carried out in the presence of stoichiometric amounts of tetrachloro-p-benzoquinone (chloranil), only quinolines 3 are obtained.