cleomiscosin A | 1013663-92-7

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 香豆素木脂素
• 英文名称: cleomiscosin A
• 英文别名: cleomiscosine A；(2R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one
• CAS: 1013663-92-7
• 化学式: C₂₀H₁₈O₈
• 分子量: 386.358
• InChiKey: OCBGWPJNUZMLCA-LDCVWXEPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• IMMUNOMODULATORY PHARMACEUTICAL COMPOSITION AND A PROCESS FOR PREPARATION THEREOF
  申请人：Khanuja Suman Preet Singh

  公开号：US20110092585A1

  公开（公告）日：2011-04-21

  The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscosa along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.