tri(ethylene glycol)-1-butene | 220568-10-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tri(ethylene glycol)-1-butene
• 英文别名: 2-[2-(2-But-3-enoxyethoxy)ethoxy]ethanol；2-[2-(2-but-3-enoxyethoxy)ethoxy]ethanol
• CAS: 220568-10-5
• 化学式: C₁₀H₂₀O₄
• 分子量: 204.266
• InChiKey: ISEVGBUKKZQRRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tri(ethylene glycol)-1-butene 在 氢氧化钾 、 1,2-二溴乙烷 、 lithium diisopropyl amide 作用下， 反应 25.0h， 生成 1,2-bis(5''-(4,7,10,13-tetraoxaheptadec-16-en-1-yl)-[2,2':6',2''-terpyridin]-5-yl)ethane
  参考文献：
  名称：

  Copper(I)- or Iron(II)-Templated Synthesis of Molecular Knots Containing Two Tetrahedral or Octahedral Coordination Sites

  摘要：

  Molecular trefoil knots have been prepared from metal-assembled precursors using the ring closing metathesis (RCM) cyclization methodology. The templating metal is either copper(I) or iron(II) and the coordinating fragments 1,10-phenanthroline or 2,2':6',2 "-terpyridine, respectively. The RCM approach, newly applied to the field of catenanes and knots, represents a spectacular synthetic improvement in terms of yield and experimental conditions (no high dilution required). The dicopper(I) trefoil knot has been synthesized in a 74% yield. A similar approach also led to the first knot constructed around two iron(II) bis(terpyridine) moieties, demonstrating that iron(II) can also be used as a highly efficient template. Moreover, for both Cu(I) and Fe(II) knots, it has been possible to quantitatively reduce the cyclic olefins formed during the macrocyclization by catalytic (Pd/C) hydrogenation. An X-ray structure of the double helix of iron(II) bis(1,2-bis(5-(5 "-methyl-2,2':6',2 "-terpyridinyl))ethane) is given which shows that the double-stranded helical precursor is well predisposed for the formation of a molecular knot.

  DOI：

  10.1021/ja982239+
• 作为产物：
  描述：

  mono(tetrahydropyranyl) monobromide 在 氢氧化钾 、 对甲苯磺酸 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 tri(ethylene glycol)-1-butene
  参考文献：
  名称：

  Copper(I)- or Iron(II)-Templated Synthesis of Molecular Knots Containing Two Tetrahedral or Octahedral Coordination Sites

  摘要：

  Molecular trefoil knots have been prepared from metal-assembled precursors using the ring closing metathesis (RCM) cyclization methodology. The templating metal is either copper(I) or iron(II) and the coordinating fragments 1,10-phenanthroline or 2,2':6',2 "-terpyridine, respectively. The RCM approach, newly applied to the field of catenanes and knots, represents a spectacular synthetic improvement in terms of yield and experimental conditions (no high dilution required). The dicopper(I) trefoil knot has been synthesized in a 74% yield. A similar approach also led to the first knot constructed around two iron(II) bis(terpyridine) moieties, demonstrating that iron(II) can also be used as a highly efficient template. Moreover, for both Cu(I) and Fe(II) knots, it has been possible to quantitatively reduce the cyclic olefins formed during the macrocyclization by catalytic (Pd/C) hydrogenation. An X-ray structure of the double helix of iron(II) bis(1,2-bis(5-(5 "-methyl-2,2':6',2 "-terpyridinyl))ethane) is given which shows that the double-stranded helical precursor is well predisposed for the formation of a molecular knot.

  DOI：

  10.1021/ja982239+

文献信息

• Visible‐Light‐Induced Cysteine‐Specific Bioconjugation: Biocompatible Thiol–Ene Click Chemistry
  作者：Hangyeol Choi、Myojeong Kim、Jaebong Jang、Sungwoo Hong

  DOI：10.1002/anie.202010217

  日期：2020.12.7

  photosensitizing ability to activate the S−H bond of cysteine. The slightly modified QCAT enables the effective photocatalytic cysteine‐specific conjugation of biologically relevant groups. The superior reactivity and cysteine selectivity of this methodology was further corroborated by traceless bioconjugation with a series of complex peptides and proteins under biocompatible conditions.

  使用可见光光催化的生物共轭方法已经成为在温和的反应条件下选择性修饰生物分子的强大合成工具。然而，由于需要严格的反应条件，使得成功进行蛋白质生物缀合的光化学转化的数目仍然受到限制。本文中，我们报道了一种新开发的与水相容的荧光光敏剂Q PEG，可利用其固有的光敏能力激活半胱氨酸的S-H键，从而用于可见光诱导的半胱氨酸特异性生物缀合，以用于Q PEG的安装。稍微修改的Q CAT可以使生物学上相关的组有效地进行光催化的半胱氨酸特异性缀合。通过在生物相容性条件下与一系列复杂的肽和蛋白质进行无痕生物缀合，进一步证实了该方法的优异反应性和半胱氨酸选择性。
• Supramolecular gold nanoparticle–polymer composites formed in water with cucurbit[8]uril
  作者：Roger J. Coulston、Samuel T. Jones、Tung-Chun Lee、Eric A. Appel、Oren A. Scherman

  DOI：10.1039/c0cc03250f

  日期：——

  A gold nanoparticle–polymer composite material has been prepared in water using cucurbit[8]uril as a supramolecular “handcuff” to hold together viologen-functionalised gold nanoparticles and a naphthol-functionalised acrylamide copolymer.

  利用葫芦[8]脲作为超分子 "手铐"，在水中制备了一种金纳米粒子与聚合物的复合材料，将病毒官能化的金纳米粒子和萘酚官能化的丙烯酰胺共聚物固定在一起。
• COMPOSITION FOR EXTERNAL USE
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：EP1849481A1

  公开（公告）日：2007-10-31

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.

  本发明的目的是提供一种外用组合物，其中维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛素酮和/或透明质酸的经皮吸收性得到改善。 外用组合物的制备方法是将(i)磷脂和(ii)单-或寡-乙二醇醚与(iv)至少一种生物活性成分混合在一起，这些生物活性成分选自透明质酸、透明质酸衍生物、维生素 A、维生素 A 衍生物、维生素 C、特定维生素 C 衍生物、黄嘌呤衍生物、泛醌及其盐类组成的组。
• Dental hydraulic temporary sealing material composition
  申请人：GC Corporation

  公开号：EP2371345A1

  公开（公告）日：2011-10-05

  To provide a dental hydraulic temporary sealing material composition setting faster than conventional composition, excellent adhesiveness with cavity, and extremely good operativity of filling in an oral cavity, the dental hydraulic temporary sealing material composition includes calcium sulfate, a vinyl acetate resin, an inorganic filler, alcohols having a boiling point of 110°C or more, and a nonionic surfactant, whereby water on a cavity can adhere, without being repelled, to a paste surface due to hydrophilic effect between an organic solvent having proper hydrophilicity and the nonionic surfactant, the water can permeate and diffuse rapidly and stably through the inside of the paste by the hydrophilic effect so as to set faster than conventional composition, and since the hydrophilic effect is effective for adhesiveness with cavity, filling property in an oral cavity becomes extremely good.

  为了提供一种牙科液压临时密封材料组合物，该组合物比传统组合物固化速度更快，与龋洞的粘附性极佳，在口腔中填充的操作性极好，该牙科液压临时密封材料组合物包括硫酸钙、醋酸乙烯树脂、无机填料、沸点为 110°C 或更高的醇和非离子表面活性剂、由于具有适当亲水性的有机溶剂和非离子表面活性剂之间的亲水效应，空腔上的水可以不被排斥地附着在膏体表面，水可以通过亲水效应快速稳定地渗透和扩散到膏体内部，从而比传统组合物凝固得更快，而且由于亲水效应可以有效地与空腔粘合，口腔的填充性能变得非常好。
• Composition For External Use
  申请人：Harada Ayako

  公开号：US20080207560A1

  公开（公告）日：2008-08-28

  An object of the present invention is to provide a composition for external use in which the percutaneous absorbability of vitamin A, vitamin A derivative(s), vitamin C, specific vitamin C derivative(s), xanthine derivative(s), ubiquinone(s) and/or hyaluronic acid is improved. The composition for external use is prepared by blending (i) a phospholipid and (ii) a mono- or oligo-glycol ether, together with (iv) at least one bioactive component selected from the group consisting of hyaluronic acid, hyaluronic acid derivatives, vitamin A, vitamin A derivatives, vitamin C, specific vitamin C derivatives, xanthine derivatives, ubiquinones, and salts thereof.