N-(1,1-二甲基乙基)-2-异丙基-5-甲基环己烷甲酰胺 | 39668-82-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: N-(1,1-二甲基乙基)-2-异丙基-5-甲基环己烷甲酰胺
• 英文名称: N-tert-Butyl-p-menthan-3-carboxamid
• 英文别名: N-(1,1-dimethylethyl)-2-isopropyl-5-methylcyclohexanecarboxamide；N-tert-butyl-p-menthane-3-carboxamide；N-t-butyl-p-menthane-3-carboxamide；Cyclohexanecarboxamide, N-(1,1-dimethylethyl)-5-methyl-2-(1-methylethyl)-；N-tert-butyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide
• CAS: 39668-82-1
• 化学式: C₁₅H₂₉NO
• 分子量: 239.401
• InChiKey: ZVKDZYPEJXGLJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-menthyl chloride 、 N-(1,1-二甲基乙基)-2-异丙基-5-甲基环己烷甲酰胺 生成 3-menthylmagnesium chloride
  参考文献：
  名称：

  Synthesis of N-t-butyl-p-menthane-3-carboxamide

  摘要：

  该发明提供了一种高效的两步反应序列，用于生产N-叔丁基-p-薄荷烷-3-羧酰胺。该过程涉及形成3-p-薄荷基镁卤化物，并将3-p-薄荷基镁卤化物与叔丁基异氰酸酯反应以形成产物。

  公开号：

  US04350832A1

文献信息

• [EN] SUBSTITUTED AZACYLES AS TRMP8 MODULATORS<br/>[FR] AZACYLES SUBSTITUÉS EN TANT QUE MODULATEURS DE TRPM8
  申请人：GIVAUDAN SA

  公开号：WO2021074281A1

  公开（公告）日：2021-04-22

  Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

  公开的是根据公式(I)定义的TRPM8调节剂，用于实现皮肤和粘膜的冷却效果。
• SYNTHESIS OF ARYL CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS
  申请人：The Procter & Gamble Company

  公开号：US20170057911A1

  公开（公告）日：2017-03-02

  Synthesis methods to produce a series of carboxamides built off of an (S)-2-amino acid backbone or an (R)-2-amino acid backbone, depending upon the desired diastereomer of the end product.

  合成方法可用于在(S)-2-氨基酸骨架或(R)-2-氨基酸骨架上构建一系列羧酰胺，具体取决于所需的最终产物的对映异构体。
• Compositions With A Cooling Effect
  申请人：The Procter & Gamble Company

  公开号：US20190330141A1

  公开（公告）日：2019-10-31

  Personal care compositions, such as oral care and skin care compositions comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers. Also, a treatment for excess adipose tissue by applying an activating compound directly to a targeted area.

  个人护理组合物，如口腔护理和皮肤护理组合物，包括一个或多个冷却剂。冷却剂提供的愉悦冷感在更快的开始、更大的强度、影响或更长的持续时间方面得到增强，这提高了组合物对消费者的吸引力和可接受性。此外，通过将活化化合物直接应用于靶向区域来治疗多余的脂肪组织。
• N-Substituted-P-Menthane-3-Carboxamide and Uses Thereof
  申请人：Furrer Stefan Michael

  公开号：US20100056636A1

  公开（公告）日：2010-03-04

  The present invention relates to substances and compositions having a physiological cooling effect on the skin and the mucosa of the body, especially of the oral cavity, throat and nose. More in particular, the present invention relates to N-substituted-p-menthane-3-carboxamides represented by the following formula (I): and esters thereof. These substances are capable of imparting and/or enhancing a physiological cooling effect in a product in which they are incorporated, much more effectively than the heretofore known N-substituted-p-menthane-3-carboxamides.

  本发明涉及对身体的皮肤和粘膜，特别是口腔、喉咙和鼻子具有生理降温效果的物质和组合物。更具体地说，本发明涉及由以下式（I）表示的N-取代-p-薄荷烷-3-羧酰胺及其酯。这些物质能够在其中被纳入的产品中赋予和/或增强生理降温效果，比迄今已知的N-取代-p-薄荷烷-3-羧酰胺更有效。
• Taste potentiator compositions and edible confectionery and chewing gum products containing same
  申请人：Boghani Navroz

  公开号：US20060286203A1

  公开（公告）日：2006-12-21

  The present invention relates to compositions and edible orally delivered products, such as confectioneries and chewing gum, which include taste potentiators to enhance the perception of active substances contained therein. More specifically, some embodiments provide potentiator compositions, which include at least one active substance and at least one taste potentiator. The active substance and/or taste potentiator may be encapsulated in some embodiments to modify the release rate of the composition upon consumption.

  本发明涉及含有口味增强剂的组合物和可口服产品，例如糖果和口香糖，以增强其中所含活性物质的感知。更具体地，一些实施例提供了口味增强剂组合物，其中包括至少一种活性物质和至少一种口味增强剂。在某些实施例中，活性物质和/或口味增强剂可能被封装以修改在消费时的组合物释放速率。