bicyclo[2.2.1]hept-2-yl-phosphane | 852061-44-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: bicyclo[2.2.1]hept-2-yl-phosphane
• 英文别名: 2-Bicyclo[2.2.1]heptanylphosphane
• CAS: 852061-44-0
• 化学式: C₇H₁₃P
• 分子量: 128.154
• InChiKey: VBZSPJJYZXPWIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  bicyclo[2.2.1]hept-2-yl-phosphane 、 乙烯 在 偶氮二异丁腈 作用下， 以 甲苯 为溶剂， 70.0~80.0 ℃ 、3.0 MPa 条件下， 反应 8.0h， 以95%的产率得到norbornyl-diethylphosphine
  参考文献：
  名称：

  Herstellung uretdiongruppenhaltiger Polyisocyanate mit Bicycloalkylphosphinen als Katalysatoren

  摘要：

  公开号：

  EP1533301B1

文献信息

• METHOD FOR PREPARING HALOGENATED ORGANOPHOSPHINES
  申请人：Zavorine Serguei I.

  公开号：US20110071319A1

  公开（公告）日：2011-03-24

  The present application relates to a process for preparing a halogenated organophosphine, comprising reacting a primary or secondary organophosphine with a halogenating agent selected from (A) a compound of formula (I): (HaI) 3 C—C(O)—X (I) wherein X is selected from alkyl, aryl, aralkyl, alkaryl, cycloalkyl, NR 1 R 2 , C(HaI) 3 , OR 3 , -0—C(O)—R 3′ , or —Y—Z—Y—C(O)—C(HaI) 3 ; R1 and R2 are each independently selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, or cycloalkyl; R3 is selected from H, alkyl, aryl, aralkyl, alkaryl, cycloalkyl, or triorganosilyl; R 3′ is selected from C(HaI) 3 , alkyl, aryl, aralkyl, alkaryl, cycloalkyl; Y is independently selected from 0 or NH; Z is independently selected from alkylene, arylene, aralkylene, alkarylene, or cycloakylene; and Hal is selected from Cl or Br; or (B) a derivative of a polyol, polyamine or polyaminoalcohol comprising two or more hydroxyl and/or amino groups, in which a hydrogen atom in each of the hydroxyl and/or amino groups is replaced with a group —C(O)—C(HaI) 3 , wherein Hal is selected from Cl or Br.

  本申请涉及一种制备卤代有机膦的方法，包括将一种一级或二级有机膦与一种卤化试剂反应，所述卤化试剂选自以下组合物：（A）式（I）的化合物：（HaI）3C—C（O）—X（I），其中X选自烷基、芳基、芳基烷基、烷芳基、环烷基、NR1R2、C（HaI）3、OR3、-0—C（O）—R3'或—Y—Z—Y—C（HaI）3；R1和R2各自独立地选自氢、烷基、芳基、芳基烷基、烷芳基或环烷基；R3选自H、烷基、芳基、芳基烷基、烷芳基、环烷基或三有机硅基；R3'选自C（HaI）3、烷基、芳基、芳基烷基、烷芳基或环烷基；Y各自独立地选自0或NH；Z各自独立地选自烷基、芳基、芳基烷基、烷芳基或环烷基；Hal选自Cl或Br；或（B）一种多元醇、多胺或多胺醇的衍生物，其中包含两个或两个以上的羟基和/或氨基团，其中每个羟基和/或氨基团中的一个氢原子被一个基团—C（O）—C（HaI）3所取代，其中Hal选自Cl或Br。
• N-ADAMANTYL BENZAMIDES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE
  申请人：HIGH POINT PHARMACEUTICALS, LLC

  公开号：US20130231341A1

  公开（公告）日：2013-09-05

  Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.

  本发明涉及一种替代苯甲酰胺基的新型抑制剂，其在治疗中的应用、包括该化合物的制药组合物、所述化合物在制药中的应用以及包括给予该化合物的治疗方法。所述化合物调节11β-羟基类固醇脱氢酶1型(11βHSD1)的活性，因此在调节该活性对疾病有益的治疗中有用，例如代谢综合征。
• Herstellung uretdiongruppenhaltiger Polyisocyanate mit Bicycloalkylphosphinen als Katalysatoren
  申请人：Bayer MaterialScience AG

  公开号：EP1533301A2

  公开（公告）日：2005-05-25

  Die Erfindung betrifft die Verwendung von speziellen Cydoalkylphosphinen als Katalysatoren für die Isocyanatdimerisierung (Uretdionbildung) und ein Verfahren zur Herstellung hoch uretdiongruppenhaltiger Polyisocyanate.

  本发明涉及使用特殊的环烷基膦作为异氰酸酯二聚化（脲二酮形成）的催化剂，以及生产含高脲二酮基团的聚异氰酸酯的工艺。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。