(1-Benzyltriazol-4-yl)-[2-methoxy-5-(2-methoxy-5-prop-2-enylphenyl)phenyl]methanone | 1360445-16-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1-Benzyltriazol-4-yl)-[2-methoxy-5-(2-methoxy-5-prop-2-enylphenyl)phenyl]methanone
• CAS: 1360445-16-4
• 化学式: C₂₇H₂₅N₃O₃
• 分子量: 439.514
• InChiKey: WMMLWTLANFKTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  66.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(5-Bromo-2-methoxyphenyl)prop-2-yn-1-ol 在 Jones reagent 、 四(三苯基膦)钯 、 sodium azide 作用下， 以 乙二醇二甲醚 、 水 、 丙酮 为溶剂， 反应 41.17h， 生成 (1-Benzyltriazol-4-yl)-[2-methoxy-5-(2-methoxy-5-prop-2-enylphenyl)phenyl]methanone
  参考文献：
  名称：

  Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity

  摘要：

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.015

文献信息

• Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity
  作者：Vemula Praveen Kumar、R. Gajendra Reddy、Duc Duy Vo、Sumana Chakravarty、Srivari Chandrasekhar、René Grée

  DOI：10.1016/j.bmcl.2011.12.015

  日期：2012.2

  A versatile synthetic route is reported towards the preparation of new analogues for potent neurotrophic agent biaryl-type lignan honokiol. A focused 24-membered library of derivatives containing five different groups at 5'-position of honokiol has been prepared in fair to good overall yields. Compared to the natural product, or to analogues with a short alkyl chain in this position, these new derivatives have lost most of the neurotrophic activity. (C) 2011 Elsevier Ltd. All rights reserved.