7,7-dimethyl-4-(3-nitrophenyl)-1-phenyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione | 302799-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7,7-dimethyl-4-(3-nitrophenyl)-1-phenyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
• 英文别名: 7,7-dimethyl-4-(3-nitrophenyl)-1-phenyl-3,4,6,8-tetrahydroquinoline-2,5-dione
• CAS: 302799-16-2
• 化学式: C₂₃H₂₂N₂O₄
• 分子量: 390.439
• InChiKey: YENPMDRUYZHTDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 3-苯胺基-5,5-二甲基环己-2-烯-1-酮 、 间硝基苯甲醛 以 乙醇 为溶剂， 反应 144.0h， 以84%的产率得到7,7-dimethyl-4-(3-nitrophenyl)-1-phenyl-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione
  参考文献：
  名称：

  Synthesis of Quinolinediones by Catalyst-Free Formal Aza-[3+2+1] Cycloaddition of Enaminones, Aldehydes and Meldrum's Acid

  摘要：

  A simple green synthesis of 4-aryl-tetrahydroquinoline-2,5-diones was developed, improving the three-component reaction of N-aryl substituted dimedone-based enaminones, aromatic aldehydes and Meldrum's acid. The method does not employ catalyst, heating or any special solvent or reaction condition, and has facile work-up and purification. Variations of enaminones and aldehydes substituents were somewhat tolerated.

  DOI：

  10.5935/0103-5053.20140106

文献信息

• Synthesis of Quinolinediones by Catalyst-Free Formal Aza-[3+2+1] Cycloaddition of Enaminones, Aldehydes and Meldrum's Acid
  作者：Silvio Cunha、Lourenço L. B. de Santana

  DOI：10.5935/0103-5053.20140106

  日期：——

  A simple green synthesis of 4-aryl-tetrahydroquinoline-2,5-diones was developed, improving the three-component reaction of N-aryl substituted dimedone-based enaminones, aromatic aldehydes and Meldrum's acid. The method does not employ catalyst, heating or any special solvent or reaction condition, and has facile work-up and purification. Variations of enaminones and aldehydes substituents were somewhat tolerated.