申请人:Sakuraba Shunji
公开号:US20090264426A1
公开(公告)日:2009-10-22
Disclosed is a compound represented by the formula (I):
Wherein R
1
and R
2
independently represent a hydrogen atom, a lower alkyl group or the like; X
1
, X
2
and X
3
independently represent a methine group or a nitrogen atom; Y
1
and Y
3
independently represent a single bond, —O— or the like; Y
2
represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z
1
and Z
2
independently represent a single bond, a C
1-4
alkylene group or the like; Ar
1
represents an aromatic carbocyclic ring or the like; and Ar
2
represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.
本发明揭示了一种化合物,其化学式为(I):其中R1和R2分别代表氢原子、低碳烷基或类似物;X1、X2和X3分别代表亚甲基基团或氮原子;Y1和Y3分别代表单键、—O—或类似物;Y2代表低碳烷基基团或类似物;W1至W4独立地代表单键、亚甲基基团或类似物;L代表单键、亚甲基基团或类似物;Z1和Z2独立地代表单键、C1-4烷基基团或类似物;Ar1代表芳香环烷基环或类似物;Ar2代表双环芳香环烷基环或类似物。该化合物可用作治疗中枢疾病、心血管疾病或代谢性疾病的药物。