N-isopropyl-N-methyl-2-naphthylamine | 110014-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-isopropyl-N-methyl-2-naphthylamine
• 英文别名: N-methyl-N-propan-2-ylnaphthalen-2-amine
• CAS: 110014-44-3
• 化学式: C₁₄H₁₇N
• 分子量: 199.296
• InChiKey: CKXBJWDHXAKSSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-异丙基甲胺 、 1-溴代萘 在 苯基锂 作用下， 生成 N-isopropyl-N-methyl-2-naphthylamine 、 N-isopropyl-N-methyl-1-naphthylamine
  参考文献：
  名称：

  Conformational studies by dynamic NMR. 32. Enantiomerization of chiral conformers in hindered naphthylamines and naphthyl nitroxides

  摘要：

  DOI：

  10.1021/jo00230a013

文献信息

• Eis inhibitors
  申请人：University of Kentucky Research Foundation

  公开号：US10208000B2

  公开（公告）日：2019-02-19

  Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.

  本文提供的新型小分子可用于抑制介导结核分枝杆菌卡那霉素耐药性的 Eis。目前公开的主题还包括一种药物组合物，其中包括本文所述的小分子抑制剂和合适的药物载体。还提供了治疗结核病的方法，包括向个体施用有效量的所公开的小分子抑制剂，以介导卡那霉素 A 抗性和治疗结核病。
• EIS INHIBITORS
  申请人：University of Kentucky Research Foundation

  公开号：US20170174639A1

  公开（公告）日：2017-06-22

  Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis . The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
• [EN] METHOD FOR DETERMINING AUTHENTICITY AND ADULTERATION OF MARKED PETROLEUM HYDROCARBONS<br/>[FR] PROCÉDÉ PERMETTANT DE DÉTERMINER L'AUTHENTICITÉ ET L'ADULTÉRATION D'HYDROCARBURES PÉTROLIERS MARQUÉS
  申请人：SICPA HOLDING SA

  公开号：WO2021110525A1

  公开（公告）日：2021-06-10

  The present invention provides a method for determining the authenticity of a petroleum hydrocarbon allegedly comprising at least one specific chemical marker, as well as a method for determining adulteration of a petroleum hydrocarbon marked with at least one specific chemical marker. The methods claimed and described herein rely upon the use of specific chemical markers in combination with laser ionization at a wavelength of between about 300 nm and about 370 nm coupled with ion mobility spectrometry or with mass spectrometry.
• Conformational studies by dynamic NMR. 32. Enantiomerization of chiral conformers in hindered naphthylamines and naphthyl nitroxides
  作者：D. Casarini、L. Lunazzi、G. Placucci、D. Macciantelli

  DOI：10.1021/jo00230a013

  日期：1987.10