5,6-tetramethylene-4-carboethixy-2-pyridone | 126814-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,6-tetramethylene-4-carboethixy-2-pyridone
• 英文别名: ethyl 2-oxo-1,2,5,6,7,8-hexahydroquinoline-4-carboxylate；Ethyl 1,2,5,6,7,8-hexahydro-2-oxoquinoline-4-carboxylate；ethyl 2-oxo-5,6,7,8-tetrahydro-1H-quinoline-4-carboxylate
• CAS: 126814-00-4
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: SMRKOKAMQPFGLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-tetramethylene-4-carboethixy-2-pyridone 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 10.0h， 以75%的产率得到2-oxo-1,2,5,6,7,8-hexahydroquinoline-4-carbohydrazide
  参考文献：
  名称：

  Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

  摘要：

  A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.096
• 作为产物：
  描述：

  环己酮 在 乙醇 、 硫酸 、 sodium hydride 、 乙酰氯 作用下， 反应 42.0h， 生成 5,6-tetramethylene-4-carboethixy-2-pyridone
  参考文献：
  名称：

  Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

  摘要：

  A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.05.096

文献信息

• Antiinflammation agents
  申请人：Browner F. Michelle

  公开号：US20070135464A1

  公开（公告）日：2007-06-14

  Compounds, compositions and methods that are useful in the treatment of inflammatory, immunoregulatory, metabolic and cell proliferative conditions or diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, metabolism and cell proliferation. The subject compounds contain fused carbocyclic or heterocyclic rings.

  本文提供了在治疗炎症、免疫调节、代谢和细胞增殖状况或疾病中有用的化合物、组合物和方法。特别地，本发明提供了调节参与炎症、代谢和细胞增殖的蛋白质表达和/或功能的化合物。所述化合物包含融合的碳环或杂环环。
• Lowe, John A.; Ewing, Frank E.; Drozda, Susan E., Synthetic Communications, 1989, vol. 19, # 17, p. 3027 - 3036
  作者：Lowe, John A.、Ewing, Frank E.、Drozda, Susan E.

  DOI：——

  日期：——
• US7186841B2
  申请人：——

  公开号：US7186841B2

  公开（公告）日：2007-03-06
• Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
  作者：Balakrishna Dulla、Baojie Wan、Scott G. Franzblau、Ravikumar Kapavarapu、Oliver Reiser、Javed Iqbal、Manojit Pal

  DOI：10.1016/j.bmcl.2012.05.096

  日期：2012.7

  A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent. (C) 2012 Elsevier Ltd. All rights reserved.