(N-((2-methyl-1,3-dioxolan-2-yl)methyl)methacrylamide) | 1548434-57-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (N-((2-methyl-1,3-dioxolan-2-yl)methyl)methacrylamide)
• 英文别名: 2-Methyl-N-[(2-methyl-1,3-dioxolan-2-yl)methyl]-2-propenamide (stabilized with 0.1% MEHQ)；2-methyl-N-[(2-methyl-1,3-dioxolan-2-yl)methyl]prop-2-enamide
• CAS: 1548434-57-6
• 化学式: C₉H₁₅NO₃
• 分子量: 185.223
• InChiKey: PPWVOSNIHGLULW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Phthalimido-acetonethylenketal 在 阻聚剂701 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 48.0h， 生成 (N-((2-methyl-1,3-dioxolan-2-yl)methyl)methacrylamide)
  参考文献：
  名称：

  POLY(OLIGOETHYLENE GLYCOL METHACRYLATE) HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF

  摘要：

  本申请涉及包含第一和第二前体聚合物的水凝胶组合物，其中前体聚合物是经过电愿-亲核反应交联的改性聚(寡乙二醇甲基丙烯酸酯)共聚物。

  公开号：

  US20160151535A1

文献信息

• Poly(oligoethylene glycol methacrylate) hydrogel compositions, and methods of use thereof
  申请人：McMaster University

  公开号：US10363340B2

  公开（公告）日：2019-07-30

  The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

  本申请涉及由第一和第二前体聚合物组成的水凝胶组合物，其中前体聚合物是通过亲电-亲核反应交联的改性聚（低聚乙二醇甲基丙烯酸酯）共聚物。
• Tuning Gelation Time and Morphology of Injectable Hydrogels Using Ketone–Hydrazide Cross-Linking
  作者：Mathew Patenaude、Scott Campbell、Dennis Kinio、Todd Hoare

  DOI：10.1021/bm401615d

  日期：2014.3.10

  Injectable, covalently in situ forming hydrogels based on poly(N-isopropylacrylamide) have been designed on the basis of mixing hydrazide-functionalized nucleophilic precursor polymers with electrophilic precursor polymers functionalized with a combination of ketone (slow reacting) and aldehyde (fast reacting) functional groups. By tuning the ratio of aldehyde:ketone functional groups as well as the total number of ketone groups in the electrophilic precursor polymer, largely independent control over hydrogel properties including gelation time (from seconds to hours), degradation kinetics (from hours to months), optical transmission (from 1 to 85%), and mechanics (over nearly 1 order of magnitude) can be achieved. In addition, ketone-functionalized precursor polymers exhibit improved cytocompatibility at even extremely high concentrations relative to polymers functionalized with aldehyde groups, even at 4-fold higher functional group densities. Overall, increasing the ketone content of the precursor copolymers can result in in situ-gellable hydrogels with improved transparency and biocompatibility and equivalent mechanics and stimuli-responsiveness while only modestly sacrificing the speed of gel formation.
• PRINTABLE HYDROGELS FOR BIOMOLECULE IMMOBILIZATION AND STABILIZATION
  申请人：McMaster University

  公开号：US20200256860A1

  公开（公告）日：2020-08-13

  The invention pertains to a printable hydrogel that can both immobilize and stabilize a wide range of biomolecules and/or cells on a substrate while restricting the access of surrounding chemicals to the biomolecule active site. Such hydrogels can be adapted to high-throughput screening applications and can discriminate between true inhibitors and promiscuous aggregating inhibitors as well as enable the determination of dose-response relationships of biomolecule and/or cell inhibitory chemicals with high accuracy.
• [EN] IN SITU GELLING ZWITTERIONIC HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS D'HYDROGEL ZWITTERIONIQUE À GÉLIFICATION IN SITU ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV MCMASTER

  公开号：WO2021237369A1

  公开（公告）日：2021-12-02

  The disclosure relates to an in situ-gelling hydrogel composition based on functionalized zwitterionic polymers. The resulting hydrogels exhibit highly anti-fouling, anti-adhesive, and lubricating properties to enable the fabrication of bulk hydrogels or hydrogel-based coatings of relevance to biomedical applications.