1-Phthalimido-acetonethylenketal | 1775-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1-Phthalimido-acetonethylenketal
• 英文别名: 2-Methyl-2-phthalimidomethyl-1,3-dioxolan；N-(2-methyl-[1,3]dioxolan-2-ylmethyl)-phthalimide；phthalimidoacetone ethylene ketal；2-[(2-Methyl-1,3-dioxolan-2-yl)methyl]-1H-isoindole-1,3(2H)-dione；2-[(2-methyl-1,3-dioxolan-2-yl)methyl]isoindole-1,3-dione
• CAS: 1775-18-4
• 化学式: C₁₃H₁₃NO₄
• 分子量: 247.251
• InChiKey: DBPLWNFKMHZONP-UHFFFAOYSA-N

物化性质

• 熔点：
  92-93 °C
• 沸点：
  368.2±17.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-Phthalimido-acetonethylenketal 在 palladium on activated charcoal sodium azide 、 氢气 、 溴 作用下， 以 乙二醇 、 二甲基亚砜 、 乙酸乙酯 为溶剂， 25.0~100.0 ℃ 、344.73 kPa 条件下， 反应 102.5h， 生成 N-<<2-(aminomethyl)-1,3-dioxolan-2-yl>methyl>phthalimide
  参考文献：
  名称：

  Synthesis of aminoalkyl-substituted imidazo[1,2-a]- and imidazo[1,5-a]benzodiazepines

  摘要：

  DOI：

  10.1021/jo00321a010
• 作为产物：
  描述：

  N-丙酮基邻苯二甲酰亚胺 在 硫酸 对甲苯磺酸 作用下， 以 乙二醇 、 苯 为溶剂， 以67 g (90%)的产率得到1-Phthalimido-acetonethylenketal
  参考文献：
  名称：

  Phthalimido alkanone, ethylene ketals

  摘要：

  式为##SPC1##的邻苯二甲酰亚胺是苯二氮杂环己烷类药物的制备中间体，其中X为NH.sub.2、N(CH.sub.3).sub.2、Cl或Br，R.sub.0和R.sub.1为氢、甲基或乙基。

  公开号：

  US03992408A1

文献信息

• [EN] ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF<br/>[FR] MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE DE TYPE ALPHA 7, LEURS DÉRIVÉS ET LEURS UTILISATIONS
  申请人：ALPHARMAGEN LLC

  公开号：WO2016144792A1

  公开（公告）日：2016-09-15

  The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of α7 nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.

  本申请涉及由式I表示的化合物，这些化合物是α7 nAChRs的新型阳性变构调节剂。该申请还披露了通过给哺乳动物施用式I化合物的有效量来增强乙酰胆碱在α7 nAChRs上的作用以治疗对增强乙酰胆碱作用敏感的疾病。
• POLY(OLIGOETHYLENE GLYCOL METHACRYLATE) HYDROGEL COMPOSITIONS, AND METHODS OF USE THEREOF
  申请人：McMaster University

  公开号：US20160151535A1

  公开（公告）日：2016-06-02

  The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

  本申请涉及包含第一和第二前体聚合物的水凝胶组合物，其中前体聚合物是经过电愿-亲核反应交联的改性聚(寡乙二醇甲基丙烯酸酯)共聚物。
• Poly(oligoethylene glycol methacrylate) hydrogel compositions, and methods of use thereof
  申请人：McMaster University

  公开号：US10363340B2

  公开（公告）日：2019-07-30

  The present application relates to hydrogel compositions comprising first and second precursor polymers, wherein the precursor polymers are modified poly(oligoethylene glycol methacrylate) copolymers that are crosslinked through electrophile-nucleophile reactions.

  本申请涉及由第一和第二前体聚合物组成的水凝胶组合物，其中前体聚合物是通过亲电-亲核反应交联的改性聚（低聚乙二醇甲基丙烯酸酯）共聚物。
• Tuning Gelation Time and Morphology of Injectable Hydrogels Using Ketone–Hydrazide Cross-Linking
  作者：Mathew Patenaude、Scott Campbell、Dennis Kinio、Todd Hoare

  DOI：10.1021/bm401615d

  日期：2014.3.10

  Injectable, covalently in situ forming hydrogels based on poly(N-isopropylacrylamide) have been designed on the basis of mixing hydrazide-functionalized nucleophilic precursor polymers with electrophilic precursor polymers functionalized with a combination of ketone (slow reacting) and aldehyde (fast reacting) functional groups. By tuning the ratio of aldehyde:ketone functional groups as well as the total number of ketone groups in the electrophilic precursor polymer, largely independent control over hydrogel properties including gelation time (from seconds to hours), degradation kinetics (from hours to months), optical transmission (from 1 to 85%), and mechanics (over nearly 1 order of magnitude) can be achieved. In addition, ketone-functionalized precursor polymers exhibit improved cytocompatibility at even extremely high concentrations relative to polymers functionalized with aldehyde groups, even at 4-fold higher functional group densities. Overall, increasing the ketone content of the precursor copolymers can result in in situ-gellable hydrogels with improved transparency and biocompatibility and equivalent mechanics and stimuli-responsiveness while only modestly sacrificing the speed of gel formation.
• GALL M.; KAMDER B. V., J. ORG. CHEM., 1981, 46, NO 8, 1575-1585
  作者：GALL M.、 KAMDER B. V.

  DOI：——

  日期：——