Bicyclo[2.2.1]heptane-2,3-dicarboxamide | 6343-10-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Bicyclo[2.2.1]heptane-2,3-dicarboxamide
• CAS: 6343-10-8
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.22
• InChiKey: CRISHQZINOBKII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] AN IMPROVED PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE<br/>[FR] PROCÉDÉ AMÉLIORÉ DE PRÉPARATION DE CHLORHYDRATE DE LURASIDONE
  申请人：JUBILANT GENERICS LTD FORMERLY JUBILANT LIFE SCIENCES DIVISION

  公开号：WO2016059649A1

  公开（公告）日：2016-04-21

  Disclosed herein is an improved process for the preparation of Lurasidone and its pharmaceutically acceptable salts via novel intermediate and use thereof for the preparation of an antipsychotic agent useful for the treatment of schizophrenia and bipolar disorder. Further, present invention provides a cost effective and eco-friendly process for producing Lurasidone hydrochloride of formula (I) substantially free of residual solvent(s) at industrial scale.

  本文披露了一种改进的工艺，通过新颖的中间体及其用途，用于制备Lurasidone及其药用可接受盐，用于制备一种抗精神分裂症和双相情感障碍治疗有用的抗精神病药物。此外，本发明提供了一种成本效益和环保的工艺，用于在工业规模上生产几乎不含残留溶剂的盐酸Lurasidone（化学式（I））。
• PROCESS OF A QUATERNARY AMMONIUM SALT USING PHOSPHATE
  申请人：AE Nobuyuki

  公开号：US20110263848A1

  公开（公告）日：2011-10-27

  The present invention relates to a novel process for preparing quaternary ammonium salt derivatives.

  本发明涉及一种制备季铵盐衍生物的新工艺。
• PROCESS OF A QUATERNARY AMMONIUM SALT
  申请人：AE Nobuyuki

  公开号：US20110263847A1

  公开（公告）日：2011-10-27

  The present invention relates to a novel process for preparing quaternary ammonium salt derivatives.

  本发明涉及一种制备季铵盐衍生物的新工艺。
• COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20170283427A1

  公开（公告）日：2017-10-05

  The present invention relates to compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of cyclophilins, and for the treatment of cyclophilin-related disorders.

  本发明涉及化合物及其药用可接受的组合物，用作环肽酶的抑制剂，并用于治疗与环肽酶相关的疾病。
• Succinimide derivates and process for preparation thereof
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0082402A2

  公开（公告）日：1983-06-29

  Succinimide derivatives representable by the following formula: wherein X and Y are combined to form a group of the formula: (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a broken line () is a single bond or a double bond) and Z is a hydrogen atom or, X and Z are combined to form a group of the formula: (wherein A and a full line are each as defined above) and Y is a hydrogen atom, R is a phenyl group, optionally substituted with halogen, C1-C4 alkyl, Cl-C4 alkoxy or trifluoromethyl, a 2-pyridyl group or a 2-pyrimidinyl group and n is an integer of 3 or 4, and pharmaceutically acceptable acid addition salts thereof, which are useful as antianxious substances.

  可由下式表示的琥珀酰亚胺衍生物： 其中，X 和 Y 组合形成式中的一个基团：（其中，A 是氧原子、亚甲基或亚乙基，伴随断线（）的满线是单键或双键），Z 是氢原子，或者，X 和 Z 组合形成式中的一个基团：（其中，A 和满线各自如上定义），Y 是氢原子，R 是苯基，可选地被卤素、C1-C4 烷基、Cl-C4 烷氧基或三氟甲基、2-吡啶基或 2-嘧啶基取代，n 是 3 或 4 的整数，以及其药学上可接受的酸加成盐，可用作抗焦虑物质。