1-(4-Bromophenyl)-3-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)urea | 6275-59-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(4-Bromophenyl)-3-(4-hydroxy-2-methyl-5-propan-2-ylphenyl)urea
• CAS: 6275-59-8
• 化学式: C₁₇H₁₉BrN₂O₂
• 分子量: 363.2
• InChiKey: NHGIZQKGWGEYJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  61.4
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• hTRPV1 chemical agents
  申请人：UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US11339122B2

  公开（公告）日：2022-05-24

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.

  本研究公开了新型二苯基脲和苄基苯磺酰胺化合物，以及抑制 TRPV1 活性的方法和使用此类化合物治疗与瞬时受体电位香草素 1 型（TRPV1）有关的疼痛的方法。
• hTRPV1 CHEMICAL AGENTS
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20180215705A1

  公开（公告）日：2018-08-02

  Novel diphenylurea and benzylbenzenesulfonamide compounds are disclosed along with methods of inhibiting the activity of TRPV1 and methods of treating pain associated with transient receptor potential vanilloid type 1 (TRPV1) using such compounds.