methyl 4-oxo-1H-quinoline-7-carboxylate hydrochloride | 1018812-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 4-oxo-1H-quinoline-7-carboxylate hydrochloride
• 英文别名: methyl 4-oxo-1H-quinoline-7-carboxylate;hydrochloride
• CAS: 1018812-85-5
• 化学式: C₁₁H₉NO₃*ClH
• 分子量: 239.658
• InChiKey: WRSUWVDAEYCQLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-氯-4-氧代-1,4-二氢-喹啉-7-羧酸甲酯 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 水 为溶剂， 20.0 ℃ 、300.01 kPa 条件下， 反应 8.0h， 以99%的产率得到methyl 4-oxo-1H-quinoline-7-carboxylate hydrochloride
  参考文献：
  名称：

  Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones

  摘要：

  This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scating-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.055

文献信息

• Strategic studies in the syntheses of novel 6,7-substituted quinolones and 7- or 6-substituted 1,6- and 1,7-naphthyridones
  作者：Rémy Morgentin、Georges Pasquet、Pascal Boutron、Frédéric Jung、Maryannick Lamorlette、Mickaël Maudet、Patrick Plé

  DOI：10.1016/j.tet.2008.01.055

  日期：2008.3

  This paper describes the different strategies devised and applied to overcome the selectivity issues in the syntheses of 6,7-disubstituted-1H-quinolin-4-one, 7-substituted-1H-1,6-naphthyridin-4-one and 6-substituted-1H-1,7-naphthyridin-4-one derivatives. They allowed us to improve the overall yields and the scating-up feasibility. Several examples illustrate these strategies with their advantages and drawbacks. (C) 2008 Elsevier Ltd. All rights reserved.