N'-[(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)sulfonyl]pyridine-4-carbohydrazide | 220654-99-9

• 物质功能分类: 有机原料 - 肼或胲的有机衍生物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N'-[(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)sulfonyl]pyridine-4-carbohydrazide
• 英文别名: N'-[(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)sulfonyl]pyridine-4-carbohydrazide
• CAS: 220654-99-9
• 化学式: C₁₁H₁₁N₅O₅S
• mdl: MFCD02339902
• 分子量: 325.3
• InChiKey: WMPAXWJRRGZHCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  155
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• IMMUNO-MODULATOR EXHIBITING ANTI-MICROBIAL AND ANTI-MYCOBACTERIAL ACTIVITIES, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATION FOR TREATING MYCOBACTERIOSES AS WELL AS LUNG CHRONIC AND NON SPECIFIC CONDITIONS, SEXUALLY TRANSMITTED DISEASES AND THE RESULTING IMMUNO-DEFICIENCY
  申请人：Reshetov, Alexandr Leonidovich

  公开号：EP1031570A1

  公开（公告）日：2000-08-30

  The present invention pertains to the field of medicine and more precisely relates to a novel immuno-modulator of the following formula which exhibits anti-microbial and anti-mycobacterial activities. This modulator is produced by reacting equimolecular amount of 6-methyluracyl-5-sulphochloride and isoniazide in acetonitrile at a high temperature. The preparation is practically not toxic (LD50 in severe conditions exceeding 7000 mg/kg) and can be used according to a given clinical tests for expressing the immuno-modulating and anti-mycobacterial activity. This preparation can be used for correcting various immuno-deficiecies including in HIV-infected patients as well as for treating mycobacterioses such as leprosy, tuberculosis, etc. This preparation can be administrated internally or parenterally. The compound described in the present invention represents the active substance of this pharmaceutical preparation, wherein said preparation can be used against secondary various immuno-deficiecies or mycobacterioses.

  本发明涉及医药领域，更确切地说是涉及一种下式的新型免疫调节剂 它具有抗微生物和抗霉菌活性。这种调节剂是通过等分子量的 6-甲基尿基-5-磺酰氯和异烟肼在乙腈中高温反应制得的。该制剂几乎无毒（严重情况下半数致死剂量超过 7000 毫克/千克），可根据特定的临床试验用于表达免疫调节和抗霉菌活性。该制剂可用于纠正包括艾滋病毒感染者在内的各种免疫缺陷，以及治疗麻风病、结核病等分枝杆菌病。这种制剂可以内服或肠外给药。本发明中所述的化合物代表了这种药物制剂的活性物质，其中所述制剂可用于治疗继发性各种免疫缺陷病或分枝杆菌病。
• US6465476B1
  申请人：——

  公开号：US6465476B1

  公开（公告）日：2002-10-15
• [EN] MEDICINAL PREPARATION<br/>[FR] PREPARATION MEDICINALE
  申请人：ZAKRYTOE AKTSIONERNOE OBSCHEST

  公开号：WO2005092344A1

  公开（公告）日：2005-10-06

  The invention relates to a medicinal preparation containing an active agent and target additives, wherein the active agent contains (2,4-dihydroxyl-6-methyl-5- pyrimidyl)-(4-pyridin-carbonyl-hydrazinyl) sulphon of formula (III) or the efficient quantity of pharmaceutically acceptable salts and isomers thereof. In addition, the inventive medicinal preparation can contain at least one type of antituberculous remedy such as isoniozid, rephampicine and pyrazinamide. Said preparation can be embodied in the form of pills, capsules, syrup and injections.