A pressure sensitive medical sealant composition comprising a) a crosslinked, swellable polymeric matrix made from an N-vinyl lactam monomer and a multi-ethylenically unsaturated compound, wherein the ethylenic groups are vinyl groups, allyl groups or methallyl groups, which groups are bonded to nitrogen or oxygen atoms; b) a plasticizer; and c) an antimicrobial. The medical sealant is highly moisture vapor transmissive and is capable of incorporating large concentrations of iodine. The composition can be used in a variety of medical applications including as a teat plug, a wound or burn dressing, or as a sealant to seal junctions between medical instruments penetrating the skin and the skin. A method of preparing the medical sealant composition in a caulkable form is also disclosed.
一种压敏型医用密封剂组合物,包括 a) 由 N-
乙烯内酰胺单体和多
乙烯不饱和化合物制成的交联、可溶胀的聚合物基体,其中
乙烯基为
乙烯基、烯丙基或甲基烯丙基,这些基团与氮原子或氧原子键合;b)
增塑剂;以及 c) 抗菌剂。这种医用密封剂具有很强的湿气透射性,并能掺入高浓度的
碘。该组合物可用于多种医疗用途,包括用作乳头塞、伤口或烧伤敷料,或用作密封剂以密封穿透皮肤的医疗器械与皮肤之间的连接处。此外,还公开了一种制备可填塞形式的医用密封剂组合物的方法。