2-[(4-fluorophenyl)sulfonylamino]-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[(4-fluorophenyl)sulfonylamino]-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]benzamide
• 化学式: C₂₅H₂₂FN₃O₃S₂
• 分子量: 495.6
• InChiKey: QDYNAGFFMUKCGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] INHIBITING USP36<br/>[FR] INHIBITION DE USP36
  申请人：INTEGRAL EARLY DISCOVERY INC

  公开号：WO2020223548A1

  公开（公告）日：2020-11-05

  The present disclosure is directed to compounds of formulas (I) - (VI), which are useful as modulators of USP36. The compounds are further useful in the inhibition of USP36 and the treatment of diseases or disorders associated with the inhibition of USP36. For instance, the disclosure is concerned with compounds and compositions for inhibition of USP36, methods of treating diseases associated with the inhibition of USP36 (e.g., certain forms of cancer), and methods of synthesis of these compounds.

  本公开涉及的化合物具有(I) - (VI)的结构式，可用作USP36的调节剂。这些化合物进一步用于抑制USP36并治疗与USP36抑制相关的疾病或疾病。例如，本公开涉及用于抑制USP36的化合物和组合物，治疗与USP36抑制相关的疾病的方法（例如，某些癌症形式），以及这些化合物的合成方法。
• INHIBITING USP36
  申请人：Valo Health, Inc.

  公开号：US20220213088A1

  公开（公告）日：2022-07-07

  The present disclosure is directed to compounds of formulas (I)-(VI), which are useful as modulators of USP36. The compounds are further useful in the inhibition of USP36 and the treatment of diseases or disorders associated with the inhibition of USP36. For instance, the disclosure is concerned with compounds and compositions for inhibition of USP36, methods of treating diseases associated with the inhibition of USP36 (e.g., certain forms of cancer), and methods of synthesis of these compounds.