1,3-bis-(2-propyl-imidazol-1-yl)-propane | 1169960-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,3-bis-(2-propyl-imidazol-1-yl)-propane
• 英文别名: 2-Propyl-1-[3-(2-propylimidazol-1-yl)propyl]imidazole
• CAS: 1169960-13-7
• 化学式: C₁₅H₂₄N₄
• 分子量: 260.382
• InChiKey: RRGIWXCJGJEXHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  35.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-丙基咪唑 、 1,3-二溴丙烷 在 sodium hydride 、 四丁基溴化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以45%的产率得到1-(4-allyl-2-propyl-imidazol-1-yl)-3-(2-propyl-imidazol-1-yl)-propane
  参考文献：
  名称：

  Synthesis and antitubercular screening of imidazole derivatives☆

  摘要：

  A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.02.013

文献信息

• Synthesis and antitubercular screening of imidazole derivatives☆
  作者：Jyoti Pandey、Vinod K. Tiwari、Shyam S. Verma、Vinita Chaturvedi、S. Bhatnagar、S. Sinha、A.N. Gaikwad、Rama P. Tripathi

  DOI：10.1016/j.ejmech.2009.02.013

  日期：2009.8

  A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization. (C) 2009 Elsevier Masson SAS. All rights reserved.