2,5-Diallyl-4,5-dimethyl-2-cyclopenten-1-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,5-Diallyl-4,5-dimethyl-2-cyclopenten-1-one
• 英文别名: 4,5-dimethyl-2,5-bis(prop-2-enyl)cyclopent-2-en-1-one
• 化学式: C₁₃H₁₈O
• 分子量: 190.28
• InChiKey: JFRIIYUSLREAMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Medical device including unitary, continuous portion of varying durometer
  申请人：Cook Incorporated

  公开号：US20030195490A1

  公开（公告）日：2003-10-16

  A medical device ( 110 ) including a catheter shaft ( 111 ) and a unitarily and continuously formed portion ( 108 ) having a varying durometer, and optionally including an expandable balloon ( 18, 118 ). One or both of the unitarily and continuously formed portion ( 108 ) and the balloon ( 18, 118 ) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.

  医疗设备 ( 110 包括导管轴( 111 )和一个整体连续形成的部分 ( 108 )具有不同的硬度，还可选择包括一个可膨胀的球囊( 18, 118 ).其中一个或两个单元式连续成型部分( 108 )和气球( 18, 118 ) 由聚酰胺弹性体和至少一种额外的交联反应物的辐照交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺、聚醚酯酰胺或聚醚酰胺，最好是尼龙嵌段共聚物。芳香族分子可以是 1,3,5-三乙基苯、1,2,4-三乙基苯和 1,3,5-三异丙苯。交联反应物可以是：(a) 二官能团材料，(b) 三官能团材料，(c) 四官能团材料，或 (d) 含有至少两个环状取代基的芳香族分子，每个环状取代基都在其中的一个苄基位点上具有可变氢。交联反应物也可以是邻苯二甲酸二烯丙酯或偏苯二马来酰亚胺。
• Irradiation conversion of thermoplastic to thermoset polymers
  申请人：——

  公开号：US20040002729A1

  公开（公告）日：2004-01-01

  Disclosed is a radiation-crosslinkable thermoplastic polymer composition, a process for the preparation thereof, an angioplasty balloon and a medical catheter made using such a composition. The composition contains a reactive monomer cross-linker facilitates cross-linking of the reaction product upon contact of the cross-linker-containing composition with energy from a radiation source.

  本发明公开了一种可辐射交联的热塑性聚合物组合物、其制备工艺、血管成形术球囊以及使用这种组合物制成的医用导管。该组合物含有活性单体交联剂，当含有交联剂的组合物与辐射源的能量接触时，可促进反应产物的交联。
• Medical device including improved expandable balloon
  申请人：Cook Incorporated

  公开号：US20040073164A1

  公开（公告）日：2004-04-15

  A medical device ( 10 ) includes a catheter shaft ( 11 ) including inner and outer catheter shafts ( 12 and 14 ), and an expandable balloon ( 18 ) carried by the catheter shaft ( 11 ). The balloon ( 18 ) is made from an irradiation cross-linked mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide. Irradiation is carried out by exposure to an electron beam or to ultraviolet, X- or gamma radiation, preferably at a total fluence of about 0.5 to about 20 megarads. The amount of the cross-linking reactant is selected to avoid the formation of gelling during the process by which the balloon ( 18 ) is made, and the amount of the cross-linking agent and the irradiation fluence are selected to give the balloon a strength generally about equal to that which would be obtained by mere irradiation.

  医疗设备 ( 10 ) 包括导管轴 ( 11 ) 包括内导管轴和外导管轴 ( 12 和 14 )和一个可膨胀球囊( 18 ）由导管轴 ( 11 ).球囊 ( 18 ) 由聚酰胺弹性体和至少一种额外的交联反应物的辐照交联混合物制成。聚酰胺弹性体可以是聚酯酰胺、聚醚酯酰胺或聚醚酰胺，最好是尼龙嵌段共聚物。交联反应物可以是：(a) 二官能团材料，(b) 三官能团材料，(c) 四官能团材料，或 (d) 含有至少两个环状取代基的芳香族分子，每个环状取代基都在其中的一个苄基位点上具有可变氢。交联反应物也可以是邻苯二甲酸二烯丙酯或偏苯二马来酰亚胺。辐照是通过暴露于电子束或紫外线、X 射线或伽马射线中进行的，总通量最好在约 0.5 至约 20 兆拉德之间。选择交联反应物的量是为了避免在球囊( 18 交联剂的用量和辐照通量的选择是为了使气球的强度与单纯辐照得到的强度大致相等。
• Reduced profile medical balloon element
  申请人：——

  公开号：US20040093008A1

  公开（公告）日：2004-05-13

  Medical dilatation balloons comprise a polymer that has the attribute of memory, and/or is crosslinked to impart memory. Such balloons exhibit a reduced tendency to overinflate at high inflation pressures. Furthermore, such balloons when shrunk radially by the application of heat while restraining axial shrinkage, exhibit customizable linear or non-linear compliance curves and lower crosslinking profile relative to the same balloon when unshrunk. Also disclosed is an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made. In addition, disclosed are (a) processes for preparing crosslinkable polymers, (b) joining crosslinked balloons to catheter systems, (c) forming shrunk balloon elements, and (d) forming an expansive element within a tube whose outer diameter is equal to the outer diameter of the tube from which it was made.
• Irradiation Conversion of Thermoplastic to Thermoset Polymers
  申请人：Zamore Alan M.

  公开号：US20100211024A1

  公开（公告）日：2010-08-19

  Disclosed is a radiation-crosslinkable thermoplastic polymer composition, a process for the preparation thereof, an angioplasty balloon and a medical catheter made using such a composition. The composition contains a reactive monomer cross-linker facilitates cross-linking of the reaction product upon contact of the cross-linker-containing composition with energy from a radiation source.