5-amino-1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 128427-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-amino-1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 5-amino-1-cyclopropyl-6,7-difluoro-8-difluoromethoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid；5-Amino-1-cyclopropyl-8-difluoromethoxy-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid；5-amino-1-cyclopropyl-8-(difluoromethoxy)-6,7-difluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 128427-03-2
• 化学式: C₁₄H₁₀F₄N₂O₄
• 分子量: 346.238
• InChiKey: SIXCGNAUIHSNPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  92.9
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  5-amino-1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 、 八氢吡咯并[3.4-b]吡啶-1-羧酸叔丁酯 在 吡啶 作用下， 反应 0.5h， 生成
  参考文献：
  名称：

  QUINOLONECARBOXYLIC ACID COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

  摘要：

  公开号：

  EP1767536B1
• 作为产物：
  描述：

  ethyl 1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-5-nitro-1,4-dihydro-4-oxoquinoline-3-carboxylate 在 铁粉 、 溶剂黄146 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 7.0h， 以84.5%的产率得到5-amino-1-cyclopropyl-6,7-difluoro-8-difluoromethoxyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  QUINOLONECARBOXYLIC ACID COMPOUNDS, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

  摘要：

  公开号：

  EP1767536B1

文献信息

• REMEDIES OR PREVENTIVES FOR AIDS
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0878194A1

  公开（公告）日：1998-11-18

  The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing as its active ingredients one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor.

  本发明提供了一种或两种或两种以上具有抗HIV活性的喹诺酮羧酸与一种或两种或两种以上的逆转录酶抑制剂或HIV蛋白酶抑制剂的联合使用，以及一种包含作为其活性成分的抗HIV活性的喹诺酮羧酸和一种或两种或两种以上的逆转录酶抑制剂或HIV蛋白酶抑制剂的艾滋病治疗剂或预防剂。
• Intermediates for certain 4-oxoquinoline-3-carboxylic acid derivatives
  申请人：Sanko Company, Limited

  公开号：US05436367A1

  公开（公告）日：1995-07-25

  Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

  式(I)的化合物：##STR1##（其中：R.sup.1代表氟代甲氧基；R.sup.2代表含氮杂环基团；R.sup.3代表氢或氨基），以及其药学上可接受的盐、酯和酰胺是有价值的抗菌剂，可以通过将类似于式(I)中R.sup.2被卤素原子取代的化合物与提供所需的基团R.sup.2的化合物反应制备而成。
• 4-oxoquinoline-3-carboxylic acid derivatives their preparation and their
  申请人：Sankyo Company, Limited

  公开号：US05496951A1

  公开（公告）日：1996-03-05

  Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy: R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

  公式（I）的化合物：##STR1##（其中：R.sup.1代表氟代甲氧基；R.sup.2代表含氮杂环基团；R.sup.3代表氢或氨基）以及其药学上可接受的盐、酯和酰胺是有价值的抗菌剂，可以通过将类似于公式（I）中R.sup.2被卤素原子所取代的化合物与提供所需R.sup.2基团的化合物反应而制备得到。
• 4-oxoquinoline-3-carboxylic acid derivatives and their use
  申请人：Sankyo Company Limited

  公开号：US05073556A1

  公开（公告）日：1991-12-17

  Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

  式(I)的化合物：##STR1##（其中：R.sup.1代表氟代甲氧基；R.sup.2代表含氮杂环基团；R.sup.3代表氢或氨基），以及其药学上可接受的盐、酯和酰胺是有价值的抗菌剂。这些化合物可以通过将类似于式(I)但其中R.sup.2被卤素原子取代的化合物与提供所需基团R.sup.2的化合物反应而制备得到。
• Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
  申请人：Guo Huiyuan

  公开号：US20070219231A1

  公开（公告）日：2007-09-20

  This invention discloses novel quinolonecarboxylic acid derivatives, pharmaceutically acceptable salts or hydrates thereof, and their preparation methods and medical uses. The compounds in this invention show potent antibacterial activity against broad-spectrum pathogenic bacteria, with favorable pharmacokinetics and very low toxicity. The quinolinecarboxylic acid derivatives, which possess a hydrogen atom or an amino group at C-5 position, cis-substituted optical or racemic 2,8-diazo-dicyclo[4,3,0]nonanyl at C-7 position, and difluoromethoxyl at C-8 position of quinolone core, have superior activity against gram-positive bacteria and broad spectrum antibacterial activity compared with the known quinolones.

  本发明揭示了新的喹诺酮羧酸衍生物，其药学上可接受的盐或水合物，以及它们的制备方法和医药用途。本发明中的化合物对广谱致病菌表现出强大的抗菌活性，具有良好的药物动力学和极低的毒性。喹诺酮羧酸衍生物在喹诺酮核心的C-5位置具有氢原子或氨基，C-7位置具有顺式取代或外消旋2,8-二氮杂二环[4,3,0]壬基，C-8位置具有二氟甲氧基，与已知的喹诺酮相比，对革兰氏阳性菌和广谱抗菌活性具有优越的活性。