1-((5-((6-(methylsulfonyl)pyridin-3-yl)oxy)-2-pyridin-2-yl-1H-indol-6-yl)methyl)pyrrolidin-2-one | 932029-35-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-((5-((6-(methylsulfonyl)pyridin-3-yl)oxy)-2-pyridin-2-yl-1H-indol-6-yl)methyl)pyrrolidin-2-one
• 英文别名: 1-[(5-([6-(methylsulfonyl)pyridin-3-yl]oxy)-2-pyridin-2-yl-1H-indol-6-yl)methyl]pyrrolidin-2-one；1-[[5-(6-methylsulfonylpyridin-3-yl)oxy-2-pyridin-2-yl-1H-indol-6-yl]methyl]pyrrolidin-2-one
• CAS: 932029-35-1
• 化学式: C₂₄H₂₂N₄O₄S
• 分子量: 462.529
• InChiKey: PQROKKWUNKOWHD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-((5-((6-(methylsulfonyl)pyridin-3-yl)oxy)-2-pyridin-2-yl-1H-indol-6-yl)methyl)pyrrolidin-2-one 、 2-(三甲基硅烷基)乙氧甲基氯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 1-[(5-([6-(methylsulfonyl)pyridin-3-yl]oxy)-2-pyridin-2-yl-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-indol-6-yl)methyl]pyrrolidin-2-one
  参考文献：
  名称：

  EP1935890

  摘要：

  公开号：
• 作为产物：
  描述：

  ethyl [4-([6-(methylsulfonyl)pyridin-3-yl]oxy)-5-[(2-oxopyrrolidin-1-yl)methyl]-2-(pyridin-2-ylethynyl)phenyl]carbamate 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 1-((5-((6-(methylsulfonyl)pyridin-3-yl)oxy)-2-pyridin-2-yl-1H-indol-6-yl)methyl)pyrrolidin-2-one
  参考文献：
  名称：

  EP1935890

  摘要：

  公开号：

文献信息

• [EN] ACETYL PYRROLIDINYL INDOLE DERIVATIVE<br/>[FR] DÉRIVÉ ACÉTYLE PYRROLIDINYLE INDOLE
  申请人：BANYU PHARMA CO LTD

  公开号：WO2010018800A1

  公开（公告）日：2010-02-18

  The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a lower alkylsulfonyl group; R2 represents a hydrogen atom; R20 represents, e.g., a hydrogen atom; m represents an integer of from 1 to 3; and n represents zero or 1, or relates to a pharmaceutically acceptable salts thereof.

  本发明涉及一种化合物，用于治疗和/或预防糖尿病、糖尿病并发症或肥胖症，因为这些化合物具有激活葡萄糖激酶的作用，并且以式（I）呈现：其中R1代表较低的烷基磺酰基；R2代表氢原子；R20代表例如氢原子；m表示1至3之间的整数；n表示零或1，或者与其药学上可接受的盐有关。
• 2-HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE
  申请人：Takahashi Keiji

  公开号：US20090118304A1

  公开（公告）日：2009-05-07

  Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, R 1 represents an aryl or the like; R 11 represents an aryl or the like; R 2 represents a formyl or the like, R 3 represents a C 1-6 alkyl or the like; R 3 represents a hydrogen atom or the like; Z 1 represents —O— or the like; Z 2 represents —O— or the like; Y 1 -Y 4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.

  本发明涉及一种化合物，其公式如下（I），具有激活葡萄糖激酶的作用，因此可用于治疗糖尿病或肥胖症，或其药学上可接受的盐。在公式中，R1代表芳基或类似物; R11代表芳基或类似物; R2代表甲酰基或类似物，R3代表C1-6烷基或类似物; R3代表氢原子或类似物; Z1代表—O—或类似物; Z2代表—O—或类似物; Y1-Y4分别代表碳原子或氮原子; 环A代表杂环芳基; X代表碳原子或类似物; m代表0-2的整数; q代表0-2的整数。
• 2-Heterocycle-substituted indole derivatives for treating diabetes and associated conditions
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US07799820B2

  公开（公告）日：2010-09-21

  Disclosed is a compound represented by the formula (I) below, which has a glucokinase-activating effect and is thus useful for treatment of diabetes or obesity, or a pharmaceutically acceptable salt thereof. In the formula, R1 represents an aryl or the like; R11 represents an aryl or the like; R2 represents a formyl or the like, R3 represents a C1-6 alkyl or the like; R3 represents a hydrogen atom or the like; Z1 represents —O— or the like; Z2 represents —O— or the like; Y1-Y4 respectively represent a carbon atom or a nitrogen atom; ring A represents a heteroaryl group; X represents a carbon atom or the like; m represents an integer of 0-2; and q represents an integer of 0-2.

  公开了一种化合物，其化学式如下（I），具有激活葡萄糖激酶的作用，因此可用于治疗糖尿病或肥胖症，或其药学上可接受的盐。在该式中，R1代表芳基或类似物；R11代表芳基或类似物；R2代表甲酰基或类似物，R3代表C1-6烷基或类似物；R3代表氢原子或类似物；Z1代表—O—或类似物；Z2代表—O—或类似物；Y1-Y4分别代表碳原子或氮原子；环A代表杂环芳基；X代表碳原子或类似物；m代表0-2的整数；q代表0-2的整数。
• EP1935890B1
  申请人：——

  公开号：EP1935890B1

  公开（公告）日：2016-03-16
• ACETYL PYRROLIDINYL INDOLE DERIVATIVE
  申请人：Imamura Hideaki

  公开号：US20120108817A1

  公开（公告）日：2012-05-03

  The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R 1 represents a lower alkylsulfonyl group; R 2 represents a hydrogen atom; R 20 represents, e.g., a hydrogen atom; m represents an integer of from 1 to 3; and n represents zero or 1, or relates to a pharmaceutically acceptable salts thereof.