Melampodin A

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Melampodin A
• 英文别名: methyl (1R,2E,4S,6R,7E,9S,10S,11S)-10-[(2R,3R)-2,3-dimethyloxirane-2-carbonyl]oxy-9-hydroxy-3-methyl-12-methylidene-13-oxo-5,14-dioxatricyclo[9.3.0.04,6]tetradeca-2,7-diene-8-carboxylate
• 化学式: C₂₁H₂₄O₉
• 分子量: 420.4
• InChiKey: ZFFQDPLDTMMAKO-PORRQQDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Dietary supplement comprising parthenolide
  申请人：——

  公开号：US20040086579A1

  公开（公告）日：2004-05-06

  An improved method for administering parthenolide and/or feverfew extract as a dietary supplement is provided, wherein an oral dosage composition comprising a dietary supplemental amount of parthenolide in a predetermined dosage amount of at least about 0.05 mg of parthenolide is orally administered to a patient. At least a portion of the administered oral dosage composition is retained by the patient in the oral cavity for a time sufficient to allow absorption of parthenolide by oral mucosal tissues. Compositions particularly suitable for oral mucosal administration of a parthenolide dietary supplement are also provided.

  本发明提供了一种作为膳食补充剂给药半苯酚内酯和/或发热草提取物的改进方法，其中向患者口服一种口服剂量组合物，该组合物包含膳食补充量的半苯酚内酯，其预定剂量至少为约0.05毫克半苯酚内酯。至少一部分口服给药组合物被患者保留在口腔中足够长的时间，以便口腔粘膜组织吸收帕芬诺尔内酯。此外，还提供了特别适用于口腔黏膜给药的非那根内酯膳食补充剂组合物。
• Compositions and methods of treatment to alleviate or prevent migrainous headaches and their associated symptoms
  申请人：——

  公开号：US20040086582A1

  公开（公告）日：2004-05-06

  Methods of treating migrainous headaches and their associated symptoms are provided by administering a composition comprising parthenolide or feverfew sublingually to a patient in need thereof. Treatments are surprisingly effective with low total administered amounts of parthenolide or feverfew. Compositions and unit dose systems are also described.

  本文提供了治疗偏头痛及其相关症状的方法，即对有需要的患者舌下含服一种由半苯酚内酯或发热草组成的组合物。令人惊奇的是，总用量较低的非那根内酯或发热草就能有效治疗偏头痛。此外，还描述了组合物和单位剂量系统。
• Sublingual methods of treatment to alleviate or prevent arthritis
  申请人：Roberts C. Stephen

  公开号：US20060222722A1

  公开（公告）日：2006-10-05

  Methods of treating arthritis and associated symptoms are provided by administering a composition comprising feverfew extract and ginger extract sublingually to a patient in need thereof. Treatments are surprisingly effective with low total administered amounts of feverfew extract and ginger extract.

  本研究提供了治疗关节炎及相关症状的方法，即给有需要的患者舌下含服一种由发热草提取物和生姜提取物组成的组合物。令人惊奇的是，在发热草提取物和生姜提取物总用量较低的情况下，治疗效果也很好。
• DIETARY SUPPLEMENT COMPRISING PARTHENOLIDE
  申请人：Gelstat Corporation

  公开号：EP1558270A1

  公开（公告）日：2005-08-03
• COMPOSITIONS AND METHODS OF TREATMENT TO ALLEVIATE OR PREVENT MIGRAINOUS HEADACHES AND THEIR ASSOCIATED SYMPTOMS
  申请人：Gelstat Corporation

  公开号：EP1558272A1

  公开（公告）日：2005-08-03