1,6-Dioxa-spiro[4.5]decan-9-one | 139704-01-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,6-Dioxa-spiro[4.5]decan-9-one
• 英文别名: 1,6-Dioxaspiro[4.5]decan-9-one
• CAS: 139704-01-1
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: MVRKHNGXDRCHKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,6-Dioxa-spiro[4.5]decan-9-one 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 1,6-Dioxaspiro<4.5>decan-9-ol
  参考文献：
  名称：

  The intramolecular silyl-modified Sakurai (ISMS) reaction. A simple and versatile synthesis of tetrahydropyrans, spiro ethers, and spiro ketals

  摘要：

  The Intramolecular Silyl Modified Sakurai (ISMS) reaction is a powerful tool for the construction of tetrahydropyrans, spiroethers, and spiroketals. The ISMS methodology was applied to a short and stereocontrolled synthesis of a minor component of the rectal gland secretion of the female Dacus oleae fruit fly.

  DOI：

  10.1021/jo00034a003
• 作为产物：
  描述：

  9-Methylidene-1,6-dioxaspiro[4.5]decane 在 sodium periodate 、 四氧化锇 、 N-甲基吲哚酮 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 生成 1,6-Dioxa-spiro[4.5]decan-9-one
  参考文献：
  名称：

  The intramolecular silyl-modified Sakurai (ISMS) reaction. A simple and versatile synthesis of tetrahydropyrans, spiro ethers, and spiro ketals

  摘要：

  The Intramolecular Silyl Modified Sakurai (ISMS) reaction is a powerful tool for the construction of tetrahydropyrans, spiroethers, and spiroketals. The ISMS methodology was applied to a short and stereocontrolled synthesis of a minor component of the rectal gland secretion of the female Dacus oleae fruit fly.

  DOI：

  10.1021/jo00034a003

文献信息

• The intramolecular silyl-modified Sakurai (ISMS) reaction. A simple and versatile synthesis of tetrahydropyrans, spiro ethers, and spiro ketals
  作者：Istvan E. Marko、Abdelaziz Mekhalfia、Daniel J. Bayston、Harry Adams

  DOI：10.1021/jo00034a003

  日期：1992.4

  The Intramolecular Silyl Modified Sakurai (ISMS) reaction is a powerful tool for the construction of tetrahydropyrans, spiroethers, and spiroketals. The ISMS methodology was applied to a short and stereocontrolled synthesis of a minor component of the rectal gland secretion of the female Dacus oleae fruit fly.
• Marko, Istvan E.; Bayston, Daniel J.; Mekhalfia, Abdelaziz, Bulletin des Societes Chimiques Belges, 1993, vol. 102, # 10, p. 655 - 662
  作者：Marko, Istvan E.、Bayston, Daniel J.、Mekhalfia, Abdelaziz、Adams, Harry

  DOI：——

  日期：——