methyl (1S,2R,6R,7R,8R,11R)-5,7,11-trihydroxy-2-methyl-2',10-dioxospiro[9-oxatricyclo[6.3.1.01,5]dodecane-6,3'-oxetane]-7-carboxylate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl (1S,2R,6R,7R,8R,11R)-5,7,11-trihydroxy-2-methyl-2',10-dioxospiro[9-oxatricyclo[6.3.1.01,5]dodecane-6,3'-oxetane]-7-carboxylate
• 化学式: C₁₆H₂₀O₉
• 分子量: 356.32
• InChiKey: BPDHZCGFGOWILW-CCZUJKKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Delivery of respiratory therapy with nasal interface
  申请人：Veliss Lee James

  公开号：US10166357B2

  公开（公告）日：2019-01-01

  A respiratory mask for continuous positive airway pressure treatment includes a cushion adapted to be positioned against the face of a patient. The cushion is configured in a gasket arrangement around an entrance to the airways of the patient. The cushion is constructed from a polyurethane foam and has a thickness of greater than about 5 mm.

  一种用于持续气道正压治疗的呼吸面罩包括一个衬垫，可抵住患者的面部。衬垫在患者气道入口周围配置成垫圈状。衬垫由聚氨酯泡沫制成，厚度大于约 5 毫米。
• Mask system comprising a combined air delivery and stabilizing structure
  申请人：ResMed Pty Ltd.

  公开号：US10556080B2

  公开（公告）日：2020-02-11

  An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

  一种用于从正压空气源向位于患者气道入口处的接口结构供气的空气输送系统，包括一个适于与正压空气源连接的歧管，以及至少一根与歧管连接并适于向接口结构输送空气的管子。每个管子的结构允许其在开放阶段（管子允许空气通过）和塌陷阶段（管子塌陷）之间移动。每个管子的结构是，典型病人头部对着床上用品的重量足以使管子从打开阶段塌陷到塌陷阶段。
• Delivery of respiratory therapy using collapsible inlet conduits
  申请人：ResMed Pty Ltd

  公开号：US10974008B2

  公开（公告）日：2021-04-13

  An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

  一种用于从正压空气源向位于患者气道入口处的接口结构供气的空气输送系统，包括一个适于与正压空气源连接的歧管，以及至少一根与歧管连接并适于向接口结构输送空气的管子。每个管子的结构允许其在开放阶段（管子允许空气通过）和塌陷阶段（管子塌陷）之间移动。每个管子的结构是，典型病人头部对着床上用品的重量足以使管子从打开阶段塌陷到塌陷阶段。
• Multicomponent respiratory therapy interface
  申请人：ResMed Pty Ltd

  公开号：US11135386B2

  公开（公告）日：2021-10-05

  An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

  一种用于从正压空气源向位于患者气道入口处的接口结构供气的空气输送系统，包括一个适于与正压空气源连接的歧管，以及至少一根与歧管连接并适于向接口结构输送空气的管子。每个管子的结构允许其在开放阶段（管子允许空气通过）和塌陷阶段（管子塌陷）之间移动。每个管子的结构是，典型病人头部对着床上用品的重量足以使管子从打开阶段塌陷到塌陷阶段。
• Delivery of respiratory therapy using conduits with varying wall thicknesses
  申请人：ResMed Pty Ltd

  公开号：US11376384B2

  公开（公告）日：2022-07-05

  An air delivery system for providing a supply of air from a source of air at positive pressure to an interfacing structure located at the entrance to the airways of a patient includes a manifold adapted to connect with the supply of positive air pressure and at least one tube connected to the manifold and adapted to deliver the supply of air to the interfacing structure. Each tube is structured to allow movement between an open phase in which the tube allows the passage of air and a collapsed phase in which the tube is collapsed. Each tube is structured such that weight of a typical patient's head against bedding apparel is sufficient to collapse the tube from the open phase to the collapsed phase.

  一种用于从正压空气源向位于患者气道入口处的接口结构供气的空气输送系统，包括一个适于与正压空气源连接的歧管，以及至少一根与歧管连接并适于向接口结构输送空气的管子。每个管子的结构允许其在开放阶段（管子允许空气通过）和塌陷阶段（管子塌陷）之间移动。每个管子的结构是，典型病人头部对着床上用品的重量足以使管子从打开阶段塌陷到塌陷阶段。