Taxchinin G | 153415-42-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Taxchinin G
• 英文别名: [(2S,4R,5R,5aS,6S,8S,9aR,10S,10aS)-2,5,10-triacetyloxy-4,8-dihydroxy-10a-(2-hydroxypropan-2-yl)-3,5a-dimethyl-9-methylidene-2,4,5,6,7,8,9a,10-octahydro-1H-benzo[f]azulen-6-yl] acetate
• CAS: 153415-42-0
• 化学式: C₂₈H₄₀O₁₁
• 分子量: 552.6
• InChiKey: KKYDBSIOPKKLQL-VZVRQYNNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• Mucoadhesive nanoparticles for cancer treatment
  申请人：Dash Alekha K.

  公开号：US20090275526A1

  公开（公告）日：2009-11-05

  The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer therapeutic agent, such as gemcitabine, taxanes, and hydrophobic cancer therapeutic agents). Also disclosed are methods for preparing such nanoparticles and pharmaceutical compositions, as well as methods for treating breast, pancreatic, colon, prostate, and other cancers by parenterally, intravenously, or otherwise administering such nanoparticles and pharmaceutical compositions.
• US8242165B2
  申请人：——

  公开号：US8242165B2

  公开（公告）日：2012-08-14
• [EN] MUCOADHESIVE NANOPARTICLES FOR CANCER TREATMENT<br/>[FR] NANOPARTICULES MUCOADHÉSIVES POUR TRAITEMENT ANTICANCÉREUX
  申请人：UNIV CREIGHTON

  公开号：WO2008105852A2

  公开（公告）日：2008-09-04

  [EN] The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer therapeutic agent, such as gemcitabine, taxanes, and hydrophobic cancer therapeutic agents). Also disclosed are methods for preparing such nanoparticles and pharmaceutical compositions, as well as methods for treating breast, pancreatic, colon, prostate, and other cancers by parenterally, intravenously, or otherwise administering such nanoparticles and pharmaceutical compositions.
  [FR] L'invention concerne une composition pharmaceutique qui comprend des nanoparticules. Les nanoparticules comprennent un monooléate ou monolinoléate de glycéryle (ou un autre ester d'acide gras); un chitosan; et un agent thérapeutique anticancéreux, tel que la gemcitabine, les taxanes, et les agents thérapeutiques anticancéreux hydrophobes. L'invention se rapporte également à des procédés de préparation desdites nanoparticules et de compositions pharmaceutiques, et à des procédés qui permettent de traiter le cancer du sein, du pancréas, du côlon, de la prostate et d'autres cancers, par l'administration parentérale, intraveineuse ou autre desdites nanoparticules et compositions pharmaceutiques.